CN: 32-1845/R
ISSN: 2095-6975
Cite this paper:
WANG Hong-Gang, LUO Fu-Kang, LEI Xiang, YAO Yun-Da, LIAO Guo-Chao, LIU Zhong-Qiu, JIANG Zhi-Hong, ZHOU Hua, WU Peng. 3, 4-seco-Labdane diterpenoids from the leaves of Callicarpa nudiflora with anti-inflammatory effects[J]. Chinese Journal of Natural Medicines, 2019, 17(9): 707-712

3, 4-seco-Labdane diterpenoids from the leaves of Callicarpa nudiflora with anti-inflammatory effects

WANG Hong-Gang1,2, LUO Fu-Kang1, LEI Xiang2, YAO Yun-Da3, LIAO Guo-Chao1, LIU Zhong-Qiu1,3, JIANG Zhi-Hong1,3, ZHOU Hua1,3, WU Peng1
1 Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China;
2 School of Translational Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China;
3 State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China
Four new 3, 4-seco-labdane diterpenoids, nudiflopenes J-M, were isolated from the leaves of Callicarpa nudiflora along with six known compounds. The structures of these diterpenoids were determined by comprehensive spectroscopic analysis. All the isolated compounds were evaluated for their inhibitory effects on NO production in LPS-stimulated RPMs and RAW264.7 cells. The results suggest that nudiflopenes J-M and other four known compounds showed significant inhibitory effects against NO production comparable to the positive control dexamethasone.
Key words:    Callicarpa nudiflora    Verbenaceae    3, 4-seco-Labdane diterpenoid    Anti-inflammatory    RPMs    RAW264.7   
Received: 2019-04-22   Revised:
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Articles by WANG Hong-Gang
Articles by LUO Fu-Kang
Articles by LEI Xiang
Articles by YAO Yun-Da
Articles by LIAO Guo-Chao
Articles by LIU Zhong-Qiu
Articles by JIANG Zhi-Hong
Articles by ZHOU Hua
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