CN: 32-1845/R
ISSN: 2095-6975
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DING Cai-Feng, DAI Zhi, YU Hao-Fei, ZHAO Xu-Dong, LUO Xiao-Dong. New aporphine alkaloids with selective cytotoxicity against glioma stem cells from Thalictrum foetidum[J]. Chinese Journal of Natural Medicines, 2019, 17(9): 698-706

New aporphine alkaloids with selective cytotoxicity against glioma stem cells from Thalictrum foetidum

DING Cai-Feng1,5, DAI Zhi1, YU Hao-Fei1,4, ZHAO Xu-Dong2, LUO Xiao-Dong1,3
1 Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2 Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Science/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, China;
3 Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China;
4 School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China;
5 University of Chinese Academy of Sciences, Beijing 100049, China
Abstract:
Seven new isoquinoline alkaloids, 9-(2'-formyl-5', 6'-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy dehydroaporphine (1), 9-(2'-formyl-5', 6'-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy oxoaporphine (2), 3-methoxy-2'-formyl oxohernandalin (3), (-)-9-(2'-methoxycarbonyl-5', 6'-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy aporphine (4), (-)-2'-methoxycarbonyl thaliadin (5), (-)-9-(2'-methoxyethyl-5', 6'-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy aporphine (6), (-)-3-methoxy hydroxyhernandalinol (7), together with six known isoquinoline alkaloids (8-13) were isolated from the roots of Thalictrum foetidum. Their structures were elucidated by extensive spectroscopic measurements. Compounds 1 and 2 showed significant selective cytotoxicity against glioma stem cells (GSC-3# and GSC-18#) with IC50 values ranging from 2.36 to 5.37 μg·mL-1.
Key words:    Thalictrum foetidum    Aporphine alkaloids    Selective cytotoxicity    Glioma stem cells   
Received: 2019-04-22   Revised:
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