CN: 32-1845/R
ISSN: 2095-6975
Cite this paper:
0
LI Yu-Ze, SONG Bei, ZHENG Xu-Dong, HUANG Wen-Li, ZHANG Hua-Wei, JIANG Yi, YUE Zheng-Gang, SONG Xiao-Mei, LIU Jian-Li. Five new polyhydroxylated furostanol saponins from the rhizomes of Tupistra chinensis[J]. Chinese Journal of Natural Medicines, 2019, 17(8): 624-630

Five new polyhydroxylated furostanol saponins from the rhizomes of Tupistra chinensis

LI Yu-Ze1, SONG Bei1,2, ZHENG Xu-Dong1, HUANG Wen-Li2, ZHANG Hua-Wei2, JIANG Yi2, YUE Zheng-Gang2, SONG Xiao-Mei2, LIU Jian-Li1
1 Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an 710069, China;
2 Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, School of Pharmacy, Shaanxi Uni-versity of Chinese Medicine, Xianyang 712046, China
Abstract:
Five new polyhydroxylated furostanol saponins were isolated from the roots and rhizomes of Tupistra chinensis, and their structures were determined as tupistrosides J-N (1-5), together with four known furostanol saponins (6-9), on the basis of physico-chemical properties and spectral analysis. Among them, compounds 3 and 5 showed cytotoxicity against human cancer cell lines SW620 with IC50 values of 72.5±2.4 and 77.3±2.5 μmol·L-1, respectively. Compound 4 showed cytotoxicity against human cancer cell line HepG2 with IC50 value of 88.6±2.1 μmol·L-1.
Key words:    Tupistra chinensis    Liliaceae    Furostanol saponins    Cytotoxicity   
Received: 2019-03-20   Revised:
Tools
PDF (557 KB) Free
Print this page
Email this article to others
Authors
Articles by LI Yu-Ze
Articles by SONG Bei
Articles by ZHENG Xu-Dong
Articles by HUANG Wen-Li
Articles by ZHANG Hua-Wei
Articles by JIANG Yi
Articles by YUE Zheng-Gang
Articles by SONG Xiao-Mei
Articles by LIU Jian-Li
References:
[1] Song XM, Liu HJ. Research and Application of "Qi-Medicines" in Taibai Mountains[M]. Beijing:People's Medical Publishing House, 2011.
[2] Wu XF, Fan JJ, Ouyang ZJ, et al. Tupistra chinensis extract attenuates murine fulminant hepatitis with multiple targets against activated T lymphocytes[J]. J Pharm Pharmacol, 2014, 66(3):453-465.
[3] Pan ZH, Li Y, Liu JL, et al. A cytotoxic cardenolide and a saponin from the rhizomes of Tupistra chinensis[J]. Fitoterapia, 2012, 83(8):1489-1493.
[4] Xiang LM, Wang YH, Yi XM, et al. Antiproliferative and anti-inflammatory furostanol saponins from the rhizomes of Tupistra chinensis[J]. Steroids, 2016, 116:28-37.
[5] Xiang LM, Wang YH, Yi XM, et al. Bioactive spirostanol saponins from the rhizome of Tupistra chinensis[J]. Steroids, 2016, 108:39-46.
[6] Liu CX, Guo ZY, Xue YH, et al. Five new furostanol saponins from the rhizomes of Tupistra chinensis[J]. Fitoterapia, 2012, 83(2):323-328.
[7] Li YZ, Wang X, He H, et al. Steroidal saponins from the roots and rhizomes of Tupistra chinensis[J]. Molecules, 2015, 20(8):13659-13669.
[8] Pan WB, Wei LM, Wei LL, et al. Chemical constituents of Tupistra chinensis rhizomes[J]. Chem Pharm Bull, 2006, 54(7):954-958.
[9] Pan WB, Chang FR, Wei LM, et al. New flavans, spirostanol sapogenins, and a pregnane genin from Tupistra chinensis and their cytotoxicity[J]. J Nat Prod, 2003, 66(2):161-168.
[10] Xiao YH, Yin HL, Chen L, et al. Three spirostanol saponins and a flavane-O-glucoside from the fresh rhizomes of Tupistra chinensis[J]. Fitoterapia, 2015, 102:102-108.
[11] Song XM, Li YZ, Zhang DD, et al. Two new spirostanol saponins from the the roots and rhizomes of Tupistra chinensis[J]. Phytochem Lett, 2015, 13:6-10.
[12] Song XM, Zhang DD, He H, et al. Steroidal glycosides from Reineckia carnea[J]. Fitoterapia, 2015, 105:240-245.
[13] Zhang DD, Wang W, Li YZ, et al. Two new pregnane glycosides from Reineckia carnea[J]. Phytochem Lett, 2016, 15:142-146.
[14] Cui YW, Yang XJ, Zhang DD, et al. Steroidal constituents from roots and rhizomes of Smilacina japonica[J]. Molecules, 2018, 23(4):798-787.
[15] Xu LL, Zou K, Wang JZ, et al. New polyhydroxylated furo-stanol saponins with inhibitory action against NO production from Tupistra chinensis rhizomes[J]. Molecules, 2007, 12(8):2029-2037.
[16] Yang QX, Zhang YJ, Li HZ, et al. Polyhydroxylated steroidal constituents from the fresh rhizomes of Tupistra yunnanensis[J]. Steroids, 2005, 70(10):732-737.
[17] Hudson CS, Dale JK. Studies on the forms of D-glucose and their mutarotation[J]. J Am Chem Soc, 1917, 39(2):320-328.
[18] Zhang XD, Chen CX, Yang JY, et al. New minor spirostane glycosides from Ypsilandra thibetica[J]. Helv Chim Acta, 2012, 95(7):1087-1093.
[19] Liu CX, Guo ZY, Deng ZS, et al. New furostanol saponins from the rhizomes of Tupistra chinensis[J]. Nat Prod Res, 2013, 27(2):123-129.
[20] Agrawal PK, Jain DC, Pathak AK. NMR spectroscopy of steroidal sapogenins and steroidal saponins:an update[J]. Magn Reson Chem, 2010, 33(12):923-953.