CN: 32-1845/R
ISSN: 2095-6975
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LIU Wei, YAN Ran, ZHANG Liang. Dendrobium sonia polysaccharide regulates immunity and restores the dysbiosis of the gut microbiota of the cyclophosphamide-induced immunosuppressed mice[J]. Chinese Journal of Natural Medicines, 2019, 17(8): 600-607

Dendrobium sonia polysaccharide regulates immunity and restores the dysbiosis of the gut microbiota of the cyclophosphamide-induced immunosuppressed mice

LIU Wei1,2, YAN Ran3, ZHANG Liang1
1 Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China;
2 Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210004, China;
3 College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 211816, China
Abstract:
To recognize the potential medicinal value of the Dendrobium sonia, polysaccharide (DSP) was extracted, purified, and investigated for its immunomodulatory activity. In vitro, DSP was shown to enhance the viability (MTT assay) and phagocytosis of macrophages. In cyclophosphamide-induced immunosuppressed mice, DSP increased serum levels of TNF-α, IL-6 and IFN-γ (enzyme-linked immunosorbent assay, ELISA), and ameliorated the imbalance of the community of gut microbiota as detected by 16S ribosomal RNA gene sequencing. These results suggest that DSP might be beneficial for patients under immunosuppressed conditions.
Key words:    Dendrobium sonia    Polysaccharides    Immunomodulatory activity    Gut microbiota   
Received: 2019-04-22   Revised:
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