CN: 32-1845/R
ISSN: 2095-6975
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WEI Shan-Shan, GAO Cai-Yun, LI Rui-Jun, KONG Ling-Yi, LUO Jun. Withaminimas A-F, six withanolides with potential an-ti-inflammatory activity from Physalis minima[J]. Chinese Journal of Natural Medicines, 2019, 17(6): 469-474

Withaminimas A-F, six withanolides with potential an-ti-inflammatory activity from Physalis minima

WEI Shan-Shan, GAO Cai-Yun, LI Rui-Jun, KONG Ling-Yi, LUO Jun
Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Tradi-tional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China
Withaminimas A-F (1-6), six new withaphysalin-type withanolides were isolated from the aerial parts of Physalis minima L.. The structures of these compounds were elucidated through a variety of spectroscopic techniques including HR-MS, NMR, and ECD. Compound 1 belongs to rare 18-norwithanolides, and 2-3 were 13/14-secowithanolides. According to the traditional usage of P. minima, inhibitory effects on nitric oxide (NO) production in lipopolysaccaride-activated RAW264.7 macrophages were evaluated, and compounds 1-4 exhibited significant inhibitory effects with IC50 values among 3.91-18.46 μmol·L-1.
Key words:    Physalis minima    Withaphysalin-type withanolides    Anti-inflammatory   
Received: 2015-04-17   Revised:
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