CN: 32-1845/R
ISSN: 2095-6975
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MIAO Lan-Yun, CHU Thi Thanh Huyen, LI Ping, JIANG Yan, LI Hui-Jun. Cimicifuga heracleifolia is therapeutically similar to black co-hosh in relieving menopausal symptoms:evidence from phar-macological and metabolomics studies[J]. Chinese Journal of Natural Medicines, 2019, 17(6): 435-445

Cimicifuga heracleifolia is therapeutically similar to black co-hosh in relieving menopausal symptoms:evidence from phar-macological and metabolomics studies

MIAO Lan-Yun1, CHU Thi Thanh Huyen1, LI Ping1, JIANG Yan2, LI Hui-Jun1
1 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China;
2 College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China
Abstract:
In the market of botanical dietary supplements, Cimicifuga heracleifolia (CH) has always been considered as an adulterated species of Cimicifuga racemosa (CR), a conventional American herb with promising benefits to counteract troubles arising from the menopause. However, the detailed comparison of their therapeutic effects is lacking. In present study, the pharmacological and metabolomics studies were comparatively conducted between CH and CR in ovariectomized (OVX) female rats. Specifically, estrogen-like, anti-hyperlipidemia and anti-osteoporosis effects were evaluated through measuring serum biochemical parameters, histopathological examination and micro computed tomography (Micro-CT) scanning. At the same time, a gas chromatography-mass spectrometry (GC-MS)-based serum metabolomics method was employed to profile the metabolite compositional changes. As a result, both CR and CH displayed anti-osteoporosis and anti-hyperlipemia on menopause syndrome. Meanwhile, their potentials in improving the OVX-induced metabolic disorders were discovered. In conclusion, these results demonstrated that CH is therapeutically similar to CR in relieving menopausal symptoms and CH could be considered as a promising alternative to CR instead of an adulterant in the market of botanical dietary supplements.
Key words:    Cimicifuga heracleifolia    Black cohosh    Menopausal symptoms    Metabolomics    Substitute   
Received: 2019-02-22   Revised:
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Articles by MIAO Lan-Yun
Articles by CHU Thi Thanh Huyen
Articles by LI Ping
Articles by JIANG Yan
Articles by LI Hui-Jun
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