CN: 32-1845/R
ISSN: 2095-6975
Cite this paper:
LIU Bing-Yu, XU Fei, BAI Jian, YAN Dao-Jiang, ZHANG Le, ZHANG Dan, HU You-Cai. Six new monacolin analogs from red yeast rice[J]. Chinese Journal of Natural Medicines, 2019, 17(5): 394-400

Six new monacolin analogs from red yeast rice

LIU Bing-Yu, XU Fei, BAI Jian, YAN Dao-Jiang, ZHANG Le, ZHANG Dan, HU You-Cai
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
Six novel monacolin analogs, monacolins V1-V6 (1-6), together with seven known ones (7-13), were isolated from the ethyl acetate extract of red yeast rice. Their structures and absolute configurations were determined by spectroscopic methods, especially 2D NMR (1H-1HCOSY, HSQC, HMBC, and NOESY/ROESY) and CD spectroscopic analyses as well as chemical derivation. Mona-colins V2 (2) and V3 (3) represent the first examples of monacolins with 3-hydroxybutyrate substitute. The anti-inflammatory inhibitory activities against the lipopolysaccharide (LPS) induced NO production in BV-2 cells as well as antioxidant activities against rat liver microsomal lipid peroxidation were evaluated.
Key words:    Monascus purpureus    Red yeast rice,Monacolins   
Received: 2019-03-26   Revised:
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