CN: 32-1845/R
ISSN: 2095-6975
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ZHOU Zhen-Zhen, ZHU Hong-Jie, YANG Cheng-Long, LIU Yan-Jun, JIANG Nan, XIAO Yong-Sheng, SHI Li-Yun, JIAO Rui-Hua, GE Hui-Ming, TAN Ren-Xiang. Dalestones A and B, two anti-inflammatory cyclopentenones from Daldinia eschscholzii with an edited strong promoter for the global regulator LaeA-like gene[J]. Chinese Journal of Natural Medicines, 2019, 17(5): 387-393

Dalestones A and B, two anti-inflammatory cyclopentenones from Daldinia eschscholzii with an edited strong promoter for the global regulator LaeA-like gene

ZHOU Zhen-Zhen1, ZHU Hong-Jie1, YANG Cheng-Long1, LIU Yan-Jun2, JIANG Nan3, XIAO Yong-Sheng1, SHI Li-Yun2, JIAO Rui-Hua1, GE Hui-Ming1, TAN Ren-Xiang1,2
1 State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing 210023, China;
2 State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing 210023, China;
3 School of Pharmacy, Nanjing Medical University, Nanjing, 210029, China
Abstract:
Replacement of the native promoter of the global regulator LaeA-like gene of Daldinia eschscholzii by a strong gpdA promoter led to the generation of two novel cyclopentenone metabolites, named dalestones A and B, whose structures were assigned by a combination of spectroscopic analysis, modified Mosher's reaction, and electronic circular dichroism (ECD). Dalestones A and B inhibit the gene expression of TNF-α and IL-6 in LPS-induced RAW264.7 macrophages.
Key words:    Daldinia eschscholzii    Global regulator    Cyclopentenone   
Received: 2019-03-27   Revised:
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Articles by ZHOU Zhen-Zhen
Articles by ZHU Hong-Jie
Articles by YANG Cheng-Long
Articles by LIU Yan-Jun
Articles by JIANG Nan
Articles by XIAO Yong-Sheng
Articles by SHI Li-Yun
Articles by JIAO Rui-Hua
Articles by GE Hui-Ming
Articles by TAN Ren-Xiang
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