CN: 32-1845/R
ISSN: 2095-6975
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WU Gao-Song, LI Hou-Kai, ZHANG Wei-Dong. Metabolomics and its application in the treatment of coronary heart disease with traditional Chinese medicine[J]. Chinese Journal of Natural Medicines, 2019, 17(5): 321-330

Metabolomics and its application in the treatment of coronary heart disease with traditional Chinese medicine

WU Gao-Song1, LI Hou-Kai1, ZHANG Wei-Dong1,2
1 Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;
2 School of Pharmacy, Second Military Medical University, Shanghai 200433, China
Abstract:
Traditional Chinese Medicine (TCM) is the treasure of Chinese Nation and gained the gradual acceptance of the international community. However, the methods and theories of TCM understanding of diseases are lack of appropriate modern scientific characterization systems. Moreover, traditional risk factors cannot promote to detection and prevent those patients with coronary artery disease (CAD) who have not developed acute myocardial infarction (MI) in time. To sum up, there is still no objective systematic evaluation system for the therapeutic mechanism of TCM in the prevention and cure of cardiovascular disease. Thus, new ideas and technologies are needed. The development of omics technology, especially metabolomics, can be used to predict the level of metabolites in vivo and diagnose the physiological state of the body in time to guide the corresponding intervention. In particular, metabolomics is also a very powerful tool to promote the modernization of TCM and the development of TCM in personalized medicine. This article summarized the application of metabolomics in the early diagnosis, the discovery of biomarkers and the treatment of TCM in CAD.
Key words:    Traditional Chinese medicine    Metabolomics    Coronary heart disease    Biomarkers    Research progress   
Received: 2019-01-23   Revised:
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Articles by WU Gao-Song
Articles by LI Hou-Kai
Articles by ZHANG Wei-Dong
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