CN: 32-1845/R
ISSN: 2095-6975
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CHEN Lin, HUANG Jia-Luo, ZHANG Lei, TIAN Hai-Yan, YIN Sheng. Jatrogricaine A: a new diterpenoid with a 5/6/6/4 carbon ring system from the stems of Jatropha podagrica[J]. Chinese Journal of Natural Medicines, 2019, 17(4): 298-302

Jatrogricaine A: a new diterpenoid with a 5/6/6/4 carbon ring system from the stems of Jatropha podagrica

CHEN Lin1, HUANG Jia-Luo1, ZHANG Lei1, TIAN Hai-Yan2, YIN Sheng1
1 School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China;
2 Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China
Abstract:
Jatrogricaine A (1), a new diterpenoid possessing a 5/6/6/4 carbon ring system, together with eight known diterpenoids (2-9) were isolated from the stems of Jatropha podagrica. Their structures were elucidated by extensive spectroscopic methods and the absolute configuration of 1 was determined by single crystal X-ray diffraction analysis. All compounds were evaluated for their anti-inflammatory activities in vitro, and compound 3 showed significant inhibitory effects against nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells with an IC50 of 13.44 ±0.28 μmol·L-1, being comparable to the positive control, quercetin (IC50 17.00 ±2.10 μmol·L-1).
Key words:    Jatropha podagrica    Euphorbiaceae    Diterpenoids    Anti-inflammatory activity   
Received: 2018-10-18   Revised:
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Articles by CHEN Lin
Articles by HUANG Jia-Luo
Articles by ZHANG Lei
Articles by TIAN Hai-Yan
Articles by YIN Sheng
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