CN: 32-1845/R
ISSN: 2095-6975
Cite this paper:
MA Cheng-Yao, LU Jia-Hui, LI Xiang, LIU Xiao, CHEN Jian-Wei. Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa[J]. Chinese Journal of Natural Medicines, 2019, 17(4): 291-297

Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa

MA Cheng-Yao1, LU Jia-Hui1, LI Xiang1, LIU Xiao2, CHEN Jian-Wei1
1 Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing 210023, China;
2 Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing 210023, China
Eight new annonaceous acetogenins, squamotin A-D (1-4), annosquatin IV-V (5 and 6), muricin O (7) and squamosten B (8), together with four known ones (9-12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1-9 against three multidrug resistance cell lines were evaluated. All tested compounds showed strong cytotoxicity.
Key words:    Annona squamosa    Annonaceous acetogenins    Cytotoxicity    Multidrug resistance   
Received: 2018-11-12   Revised:
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