CN: 32-1845/R
ISSN: 2095-6975
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GONG Wen-Xia, ZHOU Yu-Zhi, QIN Xue-Mei, DU Guan-Hua. Involvement of mitochondrial apoptotic pathway and MAPKs/NF-κB inflammatory pathway in the neuroprotective effect of atractylenolide III in corticosterone-induced PC12 cells[J]. Chinese Journal of Natural Medicines, 2019, 17(4): 264-274

Involvement of mitochondrial apoptotic pathway and MAPKs/NF-κB inflammatory pathway in the neuroprotective effect of atractylenolide III in corticosterone-induced PC12 cells

GONG Wen-Xia1, ZHOU Yu-Zhi1, QIN Xue-Mei1, DU Guan-Hua1,2
1 Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China;
2 Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
Abstract:
Atractylenolide Ⅲ (ATL-Ⅲ), a sesquiterpene compound isolated from Rhizoma Atractylodis Macrocephalae, has revealed a number of pharmacological properties including anti-inflammatory, anti-cancer activity, and neuroprotective effect. This study aimed to evaluate the cytoprotective efficiency and potential mechanisms of ATL-Ⅲ on corticosterone injured rat phaeochromocytoma (PC12) cells. Our results demonstrate that ATL-Ⅲ increases cell viability and reduces the release of lactate dehydrogenase (LDH). The results suggest that ATL-Ⅲ protects PC12 cells from corticosterone-induced injury by inhibiting the intracellular Ca2+ overloading, inhibiting the mitochondrial apoptotic pathway and modulating the MAPK/NF-κB inflammatory pathways. These findings provide a novel insight into the molecular mechanism by which ATL-Ⅲ protected the PC12 cells against corticosterone-induced injury for the first time. Our results provide the evidence that ATL-Ⅲ may serve as a therapeutic agent in the treatment of depression.
Key words:    Depression    Atractylenolide III    Corticosterone    Apoptosis    MAPKs    NF-κB   
Received: 2018-12-10   Revised:
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Articles by GONG Wen-Xia
Articles by ZHOU Yu-Zhi
Articles by QIN Xue-Mei
Articles by DU Guan-Hua
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