CN: 32-1845/R
ISSN: 2095-6975
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LI Zhao-He, ZHOU You, DING You-Xiang, GUO Qing-Long, ZHAO Li. Roles of integrin in tumor development and the target inhibitors[J]. Chinese Journal of Natural Medicines, 2019, 17(4): 241-251

Roles of integrin in tumor development and the target inhibitors

LI Zhao-He, ZHOU You, DING You-Xiang, GUO Qing-Long, ZHAO Li
State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China
Abstract:
Integrin is a large family of cell adhesion molecules (CAMs) which involves in the interaction of cells/cells and cells/extracellular matrix (ECM) to mediate cell proliferation, differentiation, adhesion, migration, etc. In recent years, aberrant expression of integrin has been clearly found in many tumor studies, indicating that integrin is closely related to tumor formation and development. Meanwhile, it has effects on tumor cell differentiation, cell migration, proliferation and tumor neovascularization. The study of drugs targeting integrins is of great significance for the clinical treatment of tumors. Because of its important role in tumorigenesis and development, integrin has become a promising target for the treatment of cancer. This review summarizes the role of integrin in tumor development and the current state of integrin inhibitors to provide a valuable reference for subsequent research.
Key words:    Integrin    Tumor development    Target therapy    Natural medicines   
Received: 2018-12-22   Revised:
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Articles by LI Zhao-He
Articles by ZHOU You
Articles by DING You-Xiang
Articles by GUO Qing-Long
Articles by ZHAO Li
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