CN: 32-1845/R
ISSN: 2095-6975
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LUO Xiao-Wei, LIN Yun, LU Yong-Jun, ZHOU Xue-Feng, LIU Yong-Hong. Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008[J]. Chinese Journal of Natural Medicines, 2019, 17(2): 149-154

Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008

LUO Xiao-Wei1,2, LIN Yun3,4, LU Yong-Jun3,4, ZHOU Xue-Feng1,2, LIU Yong-Hong1,2
1 CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China;
2 University of Chinese Academy of Sciences, Beijing 100049, China;
3 School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China;
4 Biomedical Center of Sun Yat-Sen University, Guangzhou 510275, China
Abstract:
Two new isomeric modified tripeptides, aspergillamides C and D (compounds 1 and 2), together with fifteen known compounds (compounds 3-17), were obtained from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008. The structures of the new compounds, including absolute configurations, were determined by extensive analyses of spectroscopic data (NMR, MS, UV, and IR) and comparisons between the calculated and experimental electronic circular dichroism (ECD) spectra. Butyrolactone I (compound 11) exhibited strong inhibitory effects against Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with the IC50 being 5.11 ± 0.53 μmol·L-1, and acted as a noncompetitive inhibitor based on kinetic analysis.
Key words:    Aspergillus terreus    Aspergillamides    Polyketides    MptpB inhibitor   
Received: 2018-07-17   Revised:
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Articles by LUO Xiao-Wei
Articles by LIN Yun
Articles by LU Yong-Jun
Articles by ZHOU Xue-Feng
Articles by LIU Yong-Hong
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