CN: 32-1845/R
ISSN: 2095-6975
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CAO Duo, WANG Li-Qing, HAN Xiao-Min, GUAN Hui-Rui, LEI Meng, WEI Ya-Hui, CHENG Liang, YANG Pei-Ming, SUN Zheng-Liang, GAO Wen, DAI Jia-Kun. Two symmetrical unsaturated acids isolated from Viscum album[J]. Chinese Journal of Natural Medicines, 2019, 17(2): 145-148

Two symmetrical unsaturated acids isolated from Viscum album

CAO Duo1,2, WANG Li-Qing1, HAN Xiao-Min1, GUAN Hui-Rui1, LEI Meng1, WEI Ya-Hui1, CHENG Liang2, YANG Pei-Ming2, SUN Zheng-Liang3, GAO Wen4, DAI Jia-Kun5
1 College of Life Science, Northwest University, Xi'an 710069, China;
2 State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 201203, China;
3 Shanghai University of Medicine & Health Sciences Affiliated Sixth People's Hospital South Campus, Shanghai 201499, China;
4 Shineway Pharmaceutical Group Co., Ltd., Shijiazhuang 051430, China;
5 Bio-Agricultue Institute of Shaanxi, Shaanxi 710043, China
Abstract:
In the present study, two new acetylene conjugate compounds, dibutyl (2Z, 6Z)-octa-2, 6-dien-4-yne dioate (1), and dibutyl (2E, 6E)- octa-2, 6-dien-4-yne dioate (2), were isolated from the dry stem leaves of Viscum album, along with nine known compounds (3-11). Their structures were confirmed on the basis of spectroscopic data. Compounds 1 and 8 showed antioxidant activity against xanthine oxidase (XOD) and 1,1-diphenyl-2-picrylhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydroxyl (DPPH), with the IC50 of 1.22 and 1.33 μmol·L-1, and the SC50 of 4.34 and 8.22 μmol·L-1, respectively.
Key words:    Viscum album    Symmetrical unsaturated acid    Antioxidant activity   
Received: 2018-10-20   Revised:
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Articles by CAO Duo
Articles by WANG Li-Qing
Articles by HAN Xiao-Min
Articles by GUAN Hui-Rui
Articles by LEI Meng
Articles by WEI Ya-Hui
Articles by CHENG Liang
Articles by YANG Pei-Ming
Articles by SUN Zheng-Liang
Articles by GAO Wen
Articles by DAI Jia-Kun
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