CN: 32-1845/R
ISSN: 2095-6975
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CHENG Xiao-Rui, QI Chun-Hui, WANG Tong-Xing, ZHOU Wen-Xia, ZHANG Yong-Xiang. Characteristics of the traditional Liu-Wei-Di-Huang prescription reassessed in modern pharmacology[J]. Chinese Journal of Natural Medicines, 2019, 17(2): 103-121

Characteristics of the traditional Liu-Wei-Di-Huang prescription reassessed in modern pharmacology

CHENG Xiao-Rui1,2, QI Chun-Hui1, WANG Tong-Xing1,2, ZHOU Wen-Xia1,2, ZHANG Yong-Xiang1,2
1 Academy of Military Medical Science, Institute of Pharmacology and Toxicology, Beijing 100850, China;
2 State Key Laboratory of Toxicology and Medical Countermeasures, Beijing 100850, China
Abstract:
Liu-Wei-Di-Huang (LW) is a Yin nourishing and kidney tonifying prescription in traditional Chinese medicine with promising pharmacological characteristics that can be further exploited and developed in modern medicine. We provide a comprehensive and detailed literature report on the clinical and experimental pharmacology of LW,including its quality control parameters, phytochemistry, pharmacokinetics, and toxicology. Our literature review indicates that the LW prescription possesses a unique combination of pharmacological characteristics that can be safely used for treating very different diseases. Quality control and pharmacokinetic parameters of LW are mostly based on its major bioactive phytochemical constituents. We postulate that modulating or rebalancing the neuroendocrine immunomodulation network in the body is the underlying mechanism of the multiple pharmacological activities displayed by LW.
Key words:    Liu-Wei-Di-Huang    Traditional Chinese medicine    Pharmacology    Phytochemistry    Pharmacokinetics    Toxicology   
Received: 2018-09-12   Revised:
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Articles by CHENG Xiao-Rui
Articles by QI Chun-Hui
Articles by WANG Tong-Xing
Articles by ZHOU Wen-Xia
Articles by ZHANG Yong-Xiang
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