CN: 32-1845/R
ISSN: 2095-6975
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FENG Shu-Jun, TANG Zhi-Han, WANG Ying, TANG Xin-Ying, LI Tao-Hua, TANG Wei, KUANG Ze-Min. Potential protective effects of red yeast rice in endothelial function against atherosclerotic cardiovascular disease[J]. Chinese Journal of Natural Medicines, 2019, 17(1): 50-58

Potential protective effects of red yeast rice in endothelial function against atherosclerotic cardiovascular disease

FENG Shu-Jun1, TANG Zhi-Han2,3, WANG Ying4, TANG Xin-Ying1, LI Tao-Hua2, TANG Wei2,5, KUANG Ze-Min6
1 Department of Cardiology, The First People's Hospital of Chenzhou, University of South China, Chenzhou 423000, China;
2 Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang 421001, China;
3 Department of Biochemistry and Molecular Biology, The Libin Cardiovascular Institute of Alberta, The University of Calgary, Health Sciences Center, 3330 Hospital Drive NW, Calgary T2N 4N1, Canada;
4 Department of Cardiology, The Second Affiliated Hospital of Henan University of Science and Technology, Luoyang 471000, China;
5 Class 2014, Medical College, University of South China, Hengyang 421001, China;
6 Department of Hypertension, Beijing Anzhen Hospital of Capital Medical University, Beijing 100029, China
Abstract:
Atherosclerotic cardiovascular disease (ASCVD) is the deadliest disease in the world, with endothelial injury occurring throughout the course of the disease. Therefore, improvement in endothelial function is of essential importance in the prevention of ASCVD. Red yeast rice (RYR), a healthy traditional Chinese food, has a lipid modulation function and also plays a vital role in the improvement of endothelial reactivity and cardiovascular protection; thus, it is significant in the prevention and treatment of ASCVD. This article reviews the molecular mechanisms of RYR and its related products in the improvement of endothelial function in terms of endothelial reactivity, anti-apoptosis of endothelial progenitor cells, oxidative stress alleviation and anti-inflammation.
Key words:    Red yeast rice    Xuezhikang    Atherosclerotic cardiovascular disease    Endothelial cells    Molecular mechanism   
Received: 2018-09-20   Revised:
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