CN: 32-1845/R
ISSN: 2095-6975
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WU Yu, TIAN Wen-Jing, GAO Shuo, LIAO Zu-Jian, WANG Guang-Hui, LO Jir-Mehng, LIN Pei-Hsin, ZENG De-Quan, QIU Da-Ren, LIU Xiang-Zhong, ZHOU Mi, LIN Ting, CHEN Hai-Feng. Secondary metabolites of petri-dish cultured Antrodia camphorata and their hepatoprotective activities against alcohol-induced liver injury in mice[J]. Chinese Journal of Natural Medicines, 2019, 17(1): 33-42

Secondary metabolites of petri-dish cultured Antrodia camphorata and their hepatoprotective activities against alcohol-induced liver injury in mice

WU Yu1, TIAN Wen-Jing1, GAO Shuo1, LIAO Zu-Jian1, WANG Guang-Hui1, LO Jir-Mehng2, LIN Pei-Hsin2, ZENG De-Quan1, QIU Da-Ren1, LIU Xiang-Zhong1, ZHOU Mi1, LIN Ting1, CHEN Hai-Feng1
1 Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, China;
2 Industrial Technology Research Institute, Taiwan 10001, China
Abstract:
Antrodia camphorata, a well-known and highly valued edible medicinal mushroom with intriguing activities like liver protection, has been traditionally used for the treatment of alcoholic liver disease. A. camphorata shows highly medicinal and commercial values with the demand far exceeds the available supply. Thus, the petri-dish cultured A. camphorata (PDCA) is expected to develope as a substitute. In this paper, nineteen triterpenes were isolated from PDCA, and thirteen of them were the unique anthroic acids in A. camphorata, including the main content antcin K, which suggested that PDCA produced a large array of the same anthroic acids as the wild one. Furthermore, no obvious acute toxicity was found suggesting the edible safety of PDCA. In mice alcohol-induced liver injury model, triglyceride (TG), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and malondialdehyde (MDA) had been reduced by the PDCA powder as well as the main content antcin K, which indicated that the PDCA could protect alcoholic liver injury in mice model and antcin K could be the effective component responsible for the hepatoprotective activities of PDCA against alcoholic liver diseases.
Key words:    Petri-dish    Antrodia camphorata    Hepatoprotective   
Received: 2018-10-30   Revised:
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