CN: 32-1845/R
ISSN: 2095-6975
Cite this paper:
WU Yu, TIAN Wen-Jing, GAO Shuo, LIAO Zu-Jian, WANG Guang-Hui, LO Jir-Mehng, LIN Pei-Hsin, ZENG De-Quan, QIU Da-Ren, LIU Xiang-Zhong, ZHOU Mi, LIN Ting, CHEN Hai-Feng. Secondary metabolites of petri-dish cultured Antrodia camphorata and their hepatoprotective activities against alcohol-induced liver injury in mice[J]. Chinese Journal of Natural Medicines, 2019, 17(1): 33-42

Secondary metabolites of petri-dish cultured Antrodia camphorata and their hepatoprotective activities against alcohol-induced liver injury in mice

WU Yu1, TIAN Wen-Jing1, GAO Shuo1, LIAO Zu-Jian1, WANG Guang-Hui1, LO Jir-Mehng2, LIN Pei-Hsin2, ZENG De-Quan1, QIU Da-Ren1, LIU Xiang-Zhong1, ZHOU Mi1, LIN Ting1, CHEN Hai-Feng1
1 Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, China;
2 Industrial Technology Research Institute, Taiwan 10001, China
Antrodia camphorata, a well-known and highly valued edible medicinal mushroom with intriguing activities like liver protection, has been traditionally used for the treatment of alcoholic liver disease. A. camphorata shows highly medicinal and commercial values with the demand far exceeds the available supply. Thus, the petri-dish cultured A. camphorata (PDCA) is expected to develope as a substitute. In this paper, nineteen triterpenes were isolated from PDCA, and thirteen of them were the unique anthroic acids in A. camphorata, including the main content antcin K, which suggested that PDCA produced a large array of the same anthroic acids as the wild one. Furthermore, no obvious acute toxicity was found suggesting the edible safety of PDCA. In mice alcohol-induced liver injury model, triglyceride (TG), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and malondialdehyde (MDA) had been reduced by the PDCA powder as well as the main content antcin K, which indicated that the PDCA could protect alcoholic liver injury in mice model and antcin K could be the effective component responsible for the hepatoprotective activities of PDCA against alcoholic liver diseases.
Key words:    Petri-dish    Antrodia camphorata    Hepatoprotective   
Received: 2018-10-30   Revised:
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[1] Cheng JJ, Chao CH, Lu MK. Large-scale preparation of sulfated polysaccharides with anti-angionenic and anti-inflammatory properties from Antrodia cinnamomia[J]. Int J Biol Macromol, 2018, 113(1):1198-1205.
[2] Li ZW, Kuang Y, Tang SN, Li K, et al. Hepatoprotective activities of Antrodia camphorata and its triterpenoid compounds against CCl4-induced liver injury in mice[J]. J Ethnopharmacol, 2017, 206:31-39.
[3] Yen IC, Lee SY, Lin KT, et al. In vitro anticancer activity and structural characterization of ubiquinones from Antrodia cinnamomea mycelium[J]. Molecules, 2017, 22(5):747-758.
[4] Lin WC, Deng JS, Huang SS, et al. Evaluation of antioxidant, anti-inflammatory and anti-proliferative activities of ethanol extracts from different varieties of Sanghuang species[J]. RSC Adv, 2017, 7(13):7780-7788.
[5] Liu Y, Yang A, Qu Y, et al. Ameliorative effects of Antrodia cinnamomea polysaccharides against cyclophosphamide-induced immunosuppression related to Nrf2/HO-1 signaling in BALB/c mice[J]. Int J Biol Macromol, 2018, 116:8-15.
[6] Kao ST, Kuo YH, Wang SD, et al. Analogous corticosteroids, 9A and EK100, derived from solid-state-cultured mycelium of Antrodia camphorata inhibit proinflammatory cytokine expression in macrophages[J]. Cytokine, 2018, 108:136-144.
[7] Shen CC, Kuo YC, Huang RL, et al. New ergostane and lanostane from Antrodia camphorata[J]. J Chin Med, 2003, 14(4):247-258.
[8] Cherng IH, Chiang HC, Cheng MC, et al. Three new triterpenoids from antrodia cinnamomea[J]. J Nat Prod, 1995, 58(3):365-371.
[9] Du YC, Wu TY, Chang FR, et al. Chemical profiling of the cytotoxic triterpenoid-concentrating fraction and characterization of ergostane stereo-isomer ingredients from Antrodia camphorat[J]. J Pharm Biomed Anal, 2012, 58:182-192.
[10] Cherng IH, Wu DP, Chiang HC. Triterpenoids from antrodia cinnamomea[J]. Phytochemistry, 1996, 41(1):263-267.
[11] Huang Y, Lin X, Qiao X, et al. Antcamphins A-L, ergostanoids from Antrodia camphorata[J]. J Nat Prod, 2014, 77(1):118-124.
[12] Wu SJ, Leu YL, Chen CH, et al. Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus[J]. J Nat Prod, 2010, 73(11):1756-1762.
[13] Shen CC, Wang YH, Chang TT, et al. Anti-inflammatory ergostanes from the basidiomata of Antrodia salmonea[J]. Planta Med, 2007, 73(11):1208-1213.
[14] Kwon HC, Zee SD, Cho SY, et al. Cytotoxic ergosterols from Paecilomyces sp. J300[J]. Arch Pharm Res, 2002, 25(6):851-855.
[15] Yang SW, Shen YC, Chen CH. Steroids and triterpenoids of Antodia cinnamomea-a fungus parasitic on Cinnamomum micranthum[J]. Phytochemistry, 1996, 41(5):1389-1392.
[16] Xia WU, Yang JS, Dong YS. Chemical constituents of Fomes officinalis (Ⅰ)[J]. Chin Tradit Herb Drugs, 2005, 6:812-814.
[17] Li YT, Pang DR, Zhu ZX, et al. Chemical constituents from the fruits of Vitex negundo var. cannabifolia and their biological activities in vitro[J]. Chin J Chin Mater Med, 2016, 41(22):4197-4203.
[18] Cai Z, Song L, Qian B, et al. Understanding the effect of anthocyanins extracted from purple sweet potatoes on alcohol-induced liver injury in mice[J]. Food Chem, 2018, 245:463.