CN: 32-1845/R
ISSN: 2095-6975
Cite this paper:
MEI Yu-Dan, ZHANG Nan, ZHANG Wei-Yang, TANG Jin-Shan, ZHOU Hua, YU Yang, YAO Xin-Sheng. Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities[J]. Chinese Journal of Natural Medicines, 2019, 17(1): 27-32

Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities

MEI Yu-Dan1,4, ZHANG Nan2, ZHANG Wei-Yang3, TANG Jin-Shan1, ZHOU Hua3, YU Yang1, YAO Xin-Sheng1,2
1 Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China;
2 College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;
3 Faculty of Chinese Medicine, Macau University of Science and Technology and State Key Laboratory of Quality Research in Chinese Medicine(Macau University of Science and Technology), Macau 999078, China;
4 XiangXue Academician workstation, Xiangxue Pharmaceutical Co., Ltd., Guangzhou 510663, China
The flower buds of Lonicera macranthoides (Shan Yin-Hua), represent an important traditional Chinese medicine and food ingredient. A phytochemical investigation of the 70% EtOH extract of the flower buds of L. macranthoides resulted in the isolation of 12 triterpenoids (1-12), including two new ursane-type nortriterpenes, 2α, 24-dihydroxy-23-nor-ursolic acid (1) and 2α, 4α-dihydroxy-23-nor-ursolic acid (2). Their structures were established by multiple spectroscopic methods and comparison with literature data. All isolated compounds were evaluated for their anti-inflammatory effects in LPS-activated RAW264.7 cells. Compounds 1 and 2 exhibited inhibitory effects on iNOS at the concentration of 30 μmol·L-1.
Key words:    Lonicerae Flos    Lonicera macranthoides    Ursane-type nortriterpenes    Anti-inflammation    iNOS   
Received: 2018-09-10   Revised:
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