CN: 32-1845/R
ISSN: 2095-6975
Cite this paper:
LIN Peng-Cheng, JI Lin-Lin, ZHONG Xiang-Jian, LI Jin-Jie, WANG Xin, SHANG Xiao-Ya, LIN Sheng. Taraxastane-type triterpenoids from the medicinal and edible plant Cirsium setosum[J]. Chinese Journal of Natural Medicines, 2019, 17(1): 22-26

Taraxastane-type triterpenoids from the medicinal and edible plant Cirsium setosum

LIN Peng-Cheng1, JI Lin-Lin2, ZHONG Xiang-Jian2, LI Jin-Jie2, WANG Xin2, SHANG Xiao-Ya2, LIN Sheng3
1 College of Pharmaceutical Sciences, Qinghai University for Nationalities, Xining 810000, China;
2 Beiijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China;
3 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Guided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol (1) and 22α-hydroxy-20-taraxasten-30β, 30-triol (2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD data analysis. In the TNF-α secretion inhibitory activity assay, compounds 1 and 2 were active with the IC50 of 2.6 and 3.8 μmol·L-1, respectively. In addition, compounds 1 and 2 showed moderately selective cytotoxicity against the human ovarian cancer (A2780) and colon cancer (HCT-8) cell lines.
Key words:    Cirsium setosum    Taraxastane-type triterpenoid    TNF-α secretion inhibitory activity    Cytotoxicity   
Received: 2018-10-01   Revised:
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