CN: 32-1845/R
ISSN: 2095-6975
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LIN Peng-Cheng, JI Lin-Lin, ZHONG Xiang-Jian, LI Jin-Jie, WANG Xin, SHANG Xiao-Ya, LIN Sheng. Taraxastane-type triterpenoids from the medicinal and edible plant Cirsium setosum[J]. Chinese Journal of Natural Medicines, 2019, 17(1): 22-26

Taraxastane-type triterpenoids from the medicinal and edible plant Cirsium setosum

LIN Peng-Cheng1, JI Lin-Lin2, ZHONG Xiang-Jian2, LI Jin-Jie2, WANG Xin2, SHANG Xiao-Ya2, LIN Sheng3
1 College of Pharmaceutical Sciences, Qinghai University for Nationalities, Xining 810000, China;
2 Beiijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China;
3 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Abstract:
Guided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol (1) and 22α-hydroxy-20-taraxasten-30β, 30-triol (2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD data analysis. In the TNF-α secretion inhibitory activity assay, compounds 1 and 2 were active with the IC50 of 2.6 and 3.8 μmol·L-1, respectively. In addition, compounds 1 and 2 showed moderately selective cytotoxicity against the human ovarian cancer (A2780) and colon cancer (HCT-8) cell lines.
Key words:    Cirsium setosum    Taraxastane-type triterpenoid    TNF-α secretion inhibitory activity    Cytotoxicity   
Received: 2018-10-01   Revised:
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Articles by LIN Peng-Cheng
Articles by JI Lin-Lin
Articles by ZHONG Xiang-Jian
Articles by LI Jin-Jie
Articles by WANG Xin
Articles by SHANG Xiao-Ya
Articles by LIN Sheng
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