CN: 32-1845/R
ISSN: 2095-6975
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ZHANG Qiong, ZHENG Qing-Hong, SANG Yi-Shu, SUNG Herman Ho-Yung, MIN Zhi-Da. New limonoids isolated from the bark of Melia toosendan[J]. Chinese Journal of Natural Medicines, 2018, 16(12): 946-950

New limonoids isolated from the bark of Melia toosendan

ZHANG Qiong1, ZHENG Qing-Hong1, SANG Yi-Shu2, SUNG Herman Ho-Yung3, MIN Zhi-Da2
1 Department of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China;
2 Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China;
3 Department of Chemistry, Hong Kong University of Science and Technology, Hongkong, China
Abstract:
Two new limonoids, 12-ethoxynimbolinins G and H (compounds 1 and 2), and one known compound, toosendanin (Chuanliansu) (compound 3), were isolated from the bark of Melia toosendan. Their structures were elucidated by spectroscopic analysis and X-ray techniques. The absolute configuration of toosendanin (3) was established by single-crystal X-ray diffraction. Compounds 1-3 were evaluated for their cytotoxicity against five tumor cell lines.
Key words:    Melia toosendan    Meliaceae    Limonoid    Toosendanin    Absolute configuration   
Received: 2018-10-05   Revised:
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