CN: 32-1845/R
ISSN: 2095-6975
Cite this paper:
0
CHEN Juan, YUE Jia, LIU Jiao, LIU Yun, JIAO Kai-Lin, TENG Meng-Ying, HU Chun-Yan, ZHEN Jing, WU Mao-Xuan, ZHOU Ming, LI Zhong, LI Yuan. Salvianolic acids improve liver lipid metabolism in ovariectomized rats via blocking STAT-3/SREBP1 signaling[J]. Chinese Journal of Natural Medicines, 2018, 16(11): 838-845

Salvianolic acids improve liver lipid metabolism in ovariectomized rats via blocking STAT-3/SREBP1 signaling

CHEN Juan1, YUE Jia2, LIU Jiao1, LIU Yun1, JIAO Kai-Lin1, TENG Meng-Ying1, HU Chun-Yan1, ZHEN Jing1, WU Mao-Xuan1, ZHOU Ming1, LI Zhong1, LI Yuan1
1 Department of Nutrition and Food Hygiene, School of Public Health, Nanjing Medical University, Nanjing 211166, China;
2 Department of Nutrition and Food Hygiene, School of Public Health, Gansu University of Chinese Medicine, Lanzhou 730000, China
Abstract:
Postmenopausal women, who have reduced circulating estrogen levels, are more prone to develop obesity and related metabolic diseases than premenopausal women. The absence of safe and effective treatments for postmenopausal obesity has changed the focus to natural products as alternative remedies. Total salvianolic acids (TSA) are the major water-soluble ingredients of Danshen. Salvianolic acid (SA) is the major constituent of the TSA. Salvianolic acids, including TSA and SA, are widely used in traditional Chinese medicine. In the present study, ovariectomized rats and LO2 cells were used to study the effects of salvianolic acids on body weight gain and hepatic steatosis. Salvianolic acids reduced ovariectomy (OVX)-induced body weight gain, attenuated the expressions of hepatic lipogenic genes, such as sterol regulatory element binding protein (SREBP)1, fatty acid synthase (FAS), and stearoyl-CoA desaturase (SCD)1, and decreased the liver triglyceride (TG) and total cholesterol (TC). For the molecular mechanisms, OVX and high glucose-induced phosphorylation of signal transducer and activator of transcription (STAT)-3 was inhibited by salvianolic acids treatment. In LO2 cells, inhibition of STAT-3 by siRNA attenuated the increased expression of SREBP1 and TG induced by high glucose. Salvianolic acids reduced the upregulation of SREBP1 and TG induced by high glucose in LO2 cells. In conclusion, these findings illustrated that salvianolic acids markedly alleviated the lipid metabolism disorders and protected against the postmenopausal obesity. The underlying mechanism was probably associated with the regulation of STAT-3 signaling.
Key words:    Salvianolic acids    Lipid metabolism    Weight gain    Signal transducer and activator of transcription 3   
Received: 2018-05-30   Revised:
Tools
PDF (1631 KB) Free
Print this page
Email this article to others
Authors
Articles by CHEN Juan
Articles by YUE Jia
Articles by LIU Jiao
Articles by LIU Yun
Articles by JIAO Kai-Lin
Articles by TENG Meng-Ying
Articles by HU Chun-Yan
Articles by ZHEN Jing
Articles by WU Mao-Xuan
Articles by ZHOU Ming
Articles by LI Zhong
Articles by LI Yuan
References: