CN: 32-1845/R
ISSN: 2095-6975
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ZHOU Yu, CAO Han-Bo, LI Wen-Jun, ZHAO Li. The CXCL12 (SDF-1)/CXCR4 chemokine axis: Oncogenic properties, molecular targeting, and synthetic and natural product CXCR4 inhibitors for cancer therapy[J]. Chinese Journal of Natural Medicines, 2018, 16(11): 801-810

The CXCL12 (SDF-1)/CXCR4 chemokine axis: Oncogenic properties, molecular targeting, and synthetic and natural product CXCR4 inhibitors for cancer therapy

ZHOU Yu1, CAO Han-Bo2, LI Wen-Jun2, ZHAO Li2
1 Center For Drug Evaluation, China Food and Drug Administration, Beijing 100022, China;
2 State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China
Abstract:
Chemokine 12 (CXCL12), also known as stromal cell derived factor-1 (SDF-1) and a member of the CXC chemokine subfamily, is ubiquitously expressed in many tissues and cell types. It interacts specifically with the ligand for the transmembrane G protein-coupled receptors CXCR4 and CXCR7. The CXCL12/CXCR4 axis takes part in a series of physiological, biochemical, and pathological process, such as inflammation and leukocyte trafficking, cancer-induced bone pain, and postsurgical pain, and also is a key factor in the cross-talking between tumor cells and their microenvironment. Aberrant overexpression of CXCR4 is critical for tumor survival, proliferation, angiogenesis, homing and metastasis. In this review, we summarized the role of CXCL12/CXCR4 in cancer, CXCR4 inhibitors under clinical study, and natural product CXCR4 antagonists. In conclusion, the CXCL12/CXCR4 signaling is important for tumor development and targeting the pathway might represent an effective approach to developing novel therapy in cancer treatment.
Key words:    CXCL12/CXCR4    Tumor    Targeted therapy    Plerixafor   
Received: 2018-06-17   Revised:
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Articles by ZHOU Yu
Articles by CAO Han-Bo
Articles by LI Wen-Jun
Articles by ZHAO Li
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