CN: 32-1845/R
ISSN: 2095-6975
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ZHAO Ya-Zheng, ZHANG Yuan-Yuan, HAN Han, FAN Rui-Ping, HU Yang, ZHONG Liang, KOU Jun-Ping, YU Bo-Yang. Advances in the antitumor activities and mechanisms of action of steroidal saponins[J]. Chinese Journal of Natural Medicines, 2018, 16(10): 732-748

Advances in the antitumor activities and mechanisms of action of steroidal saponins

ZHAO Ya-Zheng, ZHANG Yuan-Yuan, HAN Han, FAN Rui-Ping, HU Yang, ZHONG Liang, KOU Jun-Ping, YU Bo-Yang
Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Complex Prescription of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China
Abstract:
The steroidal saponins are one of the saponin types that exist in an unbound state and have various pharmacological activities, such as anticancer, anti-inflammatory, antiviral, antibacterial and nerves-calming properties. Cancer is a growing health problem worldwide. Significant progress has been made to understand the antitumor effects of steroidal saponins in recent years. According to reported findings, steroidal saponins exert various antitumor activities, such as inhibiting proliferation, inducing apoptosis and autophagy, and regulating the tumor microenvironment, through multiple related signaling pathways. This article focuses on the advances in domestic and foreign studies on the antitumor activity and mechanism of actions of steroidal saponins in the last five years to provide a scientific basis and research ideas for further development and clinical application of steroidal saponins.
Key words:    Steroidal saponins    Tumor    Mechanism   
Received: 2018-01-20   Revised:
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Articles by ZHAO Ya-Zheng
Articles by ZHANG Yuan-Yuan
Articles by HAN Han
Articles by FAN Rui-Ping
Articles by HU Yang
Articles by ZHONG Liang
Articles by KOU Jun-Ping
Articles by YU Bo-Yang
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