CN: 32-1845/R
ISSN: 2095-6975
Cite this paper:
Umar Farooq, Ajmal Khan, Sadia Naz, Abdur Rauf, Haroon Khan, Afsar Khan, Irfan Ullah, Syed Majid Bukhari. Sedative and antinociceptive activities of two new sesquiterpenes isolated from Ricinus communis[J]. Chinese Journal of Natural Medicines, 2018, 16(3): 225-230

Sedative and antinociceptive activities of two new sesquiterpenes isolated from Ricinus communis

Umar Farooq1, Ajmal Khan1,2, Sadia Naz1, Abdur Rauf3, Haroon Khan4, Afsar Khan1, Irfan Ullah5, Syed Majid Bukhari1
1 Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan;
2 UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Nizwa 616, Sultanate of Oman;
3 Department of Geology, University of Swabi Anbar, Khyber Pakhtunkhwa 23430, Pakistan;
4 Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan;
5 Department of Pharmacy, Abasyn University, Peshawar 25000, Pakistan
Two new sesquiterpenes, trivially named ricinusoids A (1) and ricinusoids B (2), were isolated from ethyl acetate fraction of Ricinus communis. The structures of new compounds were elucidated by detailed spectroscopic techniques, including 1D-and 2D-NMR, UV, IR spectroscopy, and mass spectrometry. The compounds (12) were also assessed for in-vivo sedative and analgesic like effects in open field and acetic acid induced writhing tests respectively at 5, 10, and 20 mg·kg−1 i.p. Pretreatment of both test compounds caused significant (P ≤ 0.05) reduction in locomotive activity like sedative agents and abdominal constrictions like analgesics. Both compounds (12) possessed marked sedative and antinociceptive effects in animal models.
Key words:    Ricinus communis    Sesquiterpenoids    Euphorbiaceae    Spectroscopic techniques    Antinociceptive activity   
Received: 2017-05-16   Revised:
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