CN: 32-1845/R
ISSN: 2095-6975
Cite this paper:
0
Chandra Sekhar Y, Phani Kumar G, Anilakumar K. R. Terminalia arjuna bark extract attenuates picrotoxin-induced behavioral changes by activation of serotonergic,dopaminergic, GABAergic and antioxidant systems [J]. Chinese Journal of Natural Medicines, 2017, 15(8): 584-596

Terminalia arjuna bark extract attenuates picrotoxin-induced behavioral changes by activation of serotonergic,dopaminergic, GABAergic and antioxidant systems

Chandra Sekhar Y, Phani Kumar G, Anilakumar K. R
Applied Nutrition Division, Defence Food Research Laboratory, DRDO, Mysore-570011, Karnataka, India
Abstract:
Stress and emotion are associated with several illnesses from headaches to heart diseases and immune deficiencies to central nervous system. Terminalia arjuna has been referred as traditional Indian medicine for several ailments. The present study aimed to elucidate the effect of T. arjuna bark extract (TA) against picrotoxin-induced anxiety. Forty two male Balb/c mice were randomly divided into six experimental groups (n=7): control, diazepam (1.5 mg·kg-1), picrotoxin (1 mg·kg-1) and three TA treatemt groups (25, 50, and 100 mg/kg). Behavioral paradigms and PCR studies were performed to determine the effect of TA against picrotoxin-induced anxiety. The results showed that TA supplementation increased locomotion towards open arm (EPM) and illuminated area (light-dark box test), and increased rearing frequency (open field test) in a dose dependent manner, compared to picrotoxin (P < 0.05). Furthermore, TA increased number of licks and shocks in Vogel's conflict. PCR studies showed an up-regulation of several genes, such as BDNF, IP3, D2L, CREB, GABAA, SOD, GPx, and GR in TA administered groups. In conclusion, alcoholic extract of TA bark showed protective activity against picrotoxin in mice by modulation of genes related to synaptic plasticity, neurotransmitters, and antioxidant enzymes.
Key words:    Anxiety    Terminalia arjuna    Gene expression    Picrotoxin    Neurotransmitters    LC-MS   
Received: 2016-08-11   Revised:
Tools
PDF (3405 KB) Free
Print this page
Email this article to others
Authors
Articles by Chandra Sekhar Y
Articles by Phani Kumar G
Articles by Anilakumar K. R
References: