CN: 32-1845/R
ISSN: 2095-6975
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CHEN Lu, WANG Wen-Ling, SONG Teng-Fei, XIE Xin, YE Xue-Wei, LIANG Ying, HUANG Hao-Cai, YAN Shi-Lun, LIAN Xiao-Yuan, ZHANG Zhi-Zhen. Anti-colorectal cancer effects of tripolinolate A from Tripolium vulgare[J]. Chinese Journal of Natural Medicines, 2017, 15(8): 576-583

Anti-colorectal cancer effects of tripolinolate A from Tripolium vulgare

CHEN Lu1, WANG Wen-Ling1, SONG Teng-Fei1, XIE Xin2, YE Xue-Wei1, LIANG Ying1, HUANG Hao-Cai1, YAN Shi-Lun1, LIAN Xiao-Yuan2, ZHANG Zhi-Zhen1
1. Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan 316021, China;
2. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
Abstract:
Tripolinolate A (TLA) is recently identified as a new compound from a halophyte plant Tripolium vulgare and has been shown to have significant in vitro activity against the proliferation of colorectal cancer and glioma cells. This study was designed to further investigate the effects of TLA on the proliferation of human normal cells, and the apoptosis and cell cycle in colorectal cancer cells, and the growth of tumors in the colorectal cancer-bearing animals. The data obtained from this study demonstrated that: 1) TLA had much less cytotoxicity in the human normal cells than the colorectal cancer cells; 2) TLA remarkably induced apoptosis in the human colorectal cancer cells and blocked cell cycle at G2/M phase, and 3) TLA had significant anti-colorectal cancer activity in the tumor-bearing animals.
Key words:    Tripolinolate A    Colorectal cancer cells    Apoptosis    Cell cycle    Anti-colorectal tumor effects   
Received: 2016-09-17   Revised:
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Articles by CHEN Lu
Articles by WANG Wen-Ling
Articles by SONG Teng-Fei
Articles by XIE Xin
Articles by YE Xue-Wei
Articles by LIANG Ying
Articles by HUANG Hao-Cai
Articles by YAN Shi-Lun
Articles by LIAN Xiao-Yuan
Articles by ZHANG Zhi-Zhen
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