CN: 32-1845/R
ISSN: 2095-6975
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GUO Hong, DONG Yu-Qing, YE Bo-Ping. Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease[J]. Chinese Journal of Natural Medicines, 2016, 14(6): 427-433

Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease

GUO Hong1,2, DONG Yu-Qing2,3, YE Bo-Ping1
1 School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China;
2 Department of Biological Sciences, Clemson University, Clemson, SC 29634, USA;
3 Institute for Engaged Aging, Clemson University, Clemson, SC 29634, USA
Abstract:
Cranberry extract (CBE) rich in polyphenols are potent to delay paralysis induced by alleviating β-amyloid (Aβ) toxicity in C. elegans model of Alzheimer's disease (AD). In order to better apply CBE as an anti-AD agent efficiently, we sought to deterrmine whether preventive or therapeutic effect contributes more prominently toward CBE's anti-AD activity. As the level of Aβ toxicity and memory health are two major pathological parameters in AD, in the present study, we compared the effects of CBE on Aβ toxicity and memory health in the C. elegans AD model treated with preventive and therapeutic protocols. Our results revealed that CBE prominently showed the preventive efficacy, providing a basis for further investigation of these effects in mammals.
Key words:    A&beta    toxicity    Cranberry polyphenols    Prevention    Body paralysis    Caenorhabditis elegans   
Received: 2015-07-01   Revised:
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Articles by GUO Hong
Articles by DONG Yu-Qing
Articles by YE Bo-Ping
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