CN: 32-1845/R
ISSN: 2095-6975
Cite this paper:
GUO Hong, DONG Yu-Qing, YE Bo-Ping. Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease[J]. Chinese Journal of Natural Medicines, 2016, 14(6): 427-433

Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease

GUO Hong1,2, DONG Yu-Qing2,3, YE Bo-Ping1
1 School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China;
2 Department of Biological Sciences, Clemson University, Clemson, SC 29634, USA;
3 Institute for Engaged Aging, Clemson University, Clemson, SC 29634, USA
Cranberry extract (CBE) rich in polyphenols are potent to delay paralysis induced by alleviating β-amyloid (Aβ) toxicity in C. elegans model of Alzheimer's disease (AD). In order to better apply CBE as an anti-AD agent efficiently, we sought to deterrmine whether preventive or therapeutic effect contributes more prominently toward CBE's anti-AD activity. As the level of Aβ toxicity and memory health are two major pathological parameters in AD, in the present study, we compared the effects of CBE on Aβ toxicity and memory health in the C. elegans AD model treated with preventive and therapeutic protocols. Our results revealed that CBE prominently showed the preventive efficacy, providing a basis for further investigation of these effects in mammals.
Key words:    A&beta    toxicity    Cranberry polyphenols    Prevention    Body paralysis    Caenorhabditis elegans   
Received: 2015-07-01   Revised:
PDF (704 KB) Free
Print this page
Email this article to others
Articles by GUO Hong
Articles by DONG Yu-Qing
Articles by YE Bo-Ping
[1] Dong Y, Guha S, Sun X, et al. Nutraceutical interventions for promoting healthy aging in invertebrate models[J]. Oxid Med Cell Longev, 2012, 2012(10):1299-1309.
[2] Fontana L, Partridge L, Longo VD. Extending healthy life span——from yeast to humans[J]. Science, 2010, 328(5976):321-326.
[3] Kenyon CJ. The genetics of ageing[J]. Nature, 2010, 464(7288):504-512.
[4] Gems D, Partridge L. Genetics of longevity in model organisms:debates and paradigm shifts[J]. Annu Rev Physiol, 2013, 75:621-644.
[5] Brookmeyer R, Gray S, Kawas C. Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset[J]. Am J Public Health, 1998, 88(9):1337-1342.
[6] Madeo J, Frieri M. Alzheimer's disease and immunotherapy[J]. Aging Dis, 2013, 4(4):210-220.
[7] Masters CL, Selkoe DJ. Biochemistry of amyloid beta-protein and amyloid deposits in Alzheimer's disease[J]. Cold Spring Harb Perspect Med, 2012, 2(6):a006262.
[8] Tejada-Vera B. Mortality from Alzheimer's disease in the United States:data for 2000 and 2010[J]. NCHS Data Brief, 2013, (116):1-8.
[9] Everitt AV, Hilmer SN, Brand-Miller JC, et al. Dietary approaches that delay age-related diseases[J]. Clin Interv Aging, 2006, 1(1):11-31.
[10] Fernandes G. Progress in nutritional immunology[J]. Immunol Res, 2008, 40(3):244-261.
[11] Masoro EJ. Dietary restriction-induced life extension:a broadly based biological phenomenon[J]. Biogerontology, 2006, 7(3):153-155.
[12] Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases[J]. Int J Biochem Cell Biol, 2009, 41(1):40-59.
[13] Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet[J]. Nature, 2006, 444(7117):337-342.
[14] DeFeudis FV, Drieu K. Ginkgo biloba extract (EGb 761) and CNS functions:basic studies and clinical applications[J]. Curr Drug Targets, 2000, 1(1):25-58.
[15] Wilson MA, Shukitt-Hale B, Kalt W, et al. Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans[J]. Aging Cell, 2006, 5(1):59-68.
[16] Blumberg JB, Camesano TA, Cassidy A, et al. Cranberries and their bioactive constituents in Human health[J]. Adv Nutr, 2013, 4(6):618-632.
[17] Pappas E, Schaich KM. Phytochemicals of cranberries and cranberry products:characterization, potential health effects, and processing stability[J]. Crit Rev Food Sci Nutr, 2009, 49(9):741-781.
[18] Guha S, Cao M, Kane RM, et al. The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1[J]. Age (Dordr), 2013, 35(5):1559-1574.
[19] Wang C, Yolitz J, Alberico T, et al. Cranberry interacts with dietary macronutrients to promote healthy aging in drosophila[J]. J Gerontol, 2014, 69(8):945-954.
[20] Dostal V, Link CD. Assaying beta-amyloid toxicity using a transgenic C. elegans model[J]. J Vis Exp, 2010, 44:10.3791/2252
[21] Link CD, Taft A, Kapulkin V, et al. Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model[J]. Neurobiol Aging, 2003, 24(3):397-413.
[22] Fonte V, Kipp DR, Yerg J, et al. Suppression of in vivo betaamyloid peptide toxicity by overexpression of the HSP-16.2 small chaperone protein[J]. J Biol Chem, 2008, 283(2):784-791.
[23] Hassan WM, Merin DA, Fonte V, et al. AIP-1 ameliorates beta-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model[J]. Hum Mol Genet, 2009, 18(15):2739-2747.
[24] Palikova I, Vostalova J, Zdarilova A, et al. Long-term effects of three commercial cranberry products on the antioxidative status in rats:a pilot study[J]. J Agric Food Chem, 2010, 58(3):1672-1678.
[25] Dinh J, Angeloni JT, Pederson DB, et al. Cranberry extract standardized for proanthocyanidins promotes the immune response of Caenorhabditis elegans to Vibrio cholerae through the p38 MAPK pathway and HSF-1[J]. PLoS One, 2014, 9(7):e103290.
[26] Guha S, Natarajan O, Murbach CG, et al. Supplement timing of cranberry extract plays a key role in promoting Caenorhabditis elegans healthspan[J]. Nutrients, 2014, 6(2):911-921.
[27] Bargmann CI, Hartwieg E, Horvitz HR. Odorant-selective genes and neurons mediate olfaction in C. elegans[J]. Cell, 1993, 74(3):515-527.
[28] de Bono M, Maricq AV. Neuronal substrates of complex behaviors in C. elegans[J]. Annu Rev Neurosci, 2005, 28:451-501.
[29] Mori I. Genetics of chemotaxis and thermotaxis in the nematode Caenorhabditis elegans[J]. Annu Rev Genet, 1999, 33:399-422.
[30] Ward S. Chemotaxis by the nematode Caenorhabditis elegans:identification of attractants and analysis of the response by use of mutants[J]. Proc Natl Acad Sci U S A, 1973, 70(3):817-821.
[31] Zhang Y, Lu H, Bargmann CI. Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans[J]. Nature, 2005, 438(7065):179-184.
[32] Sun Y, Yolitz J, Alberico T, et al. Lifespan extension by cranberry supplementation partially requires SOD2 and is life stage independent[J]. Exp Gerontol, 2013, 50:57-63.
[33] Ziv E, Hu D. Genetic variation in insulin/IGF-1 signaling pathways and longevity[J]. Ageing Res Rev, 2010, 10(2):201-204.

Related Articles:
1. TANG Jing-Jing, GENG Xiao-Ting, WANG Ya-Jing, ZHENG Tian-Yu, LU Jin-Rong, HU Rong.Synthesis and cytotoxicity evaluation of 3-amino-2-hydroxypropoxyisoflavone derivatives[J]. Chinese Journal of Natural Medicines, 2016,14(6): 462-472