CN: 32-1845/R
ISSN: 2095-6975
Cite this paper:
LI Chuan, ZHANG Jia, ZU Yu-Jiao, NIE Shu-Fang, CAO Jun, WANG Qian, NIE Shao-Ping, DENG Ze-Yuan, XIE Ming-Yong, WANG Shu. Biocompatible and biodegradable nanoparticles for enhancement of anti-cancer activities of phytochemicals[J]. Chinese Journal of Natural Medicines, 2015, 13(9): 641-652

Biocompatible and biodegradable nanoparticles for enhancement of anti-cancer activities of phytochemicals

LI Chuan1,2, ZHANG Jia1, ZU Yu-Jiao1, NIE Shu-Fang3, CAO Jun1,2, WANG Qian4, NIE Shao-Ping2, DENG Ze-Yuan2, XIE Ming-Yong2, WANG Shu1
1 Department of Nutritional Sciences, Texas Tech University, Lubbock TX 79409, USA;
2 State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China;
3 Nutrilite Health Institute, Buena Park, CA 90622, USA;
4 Department of Hematology and Oncology, The First Hospital of Jilin University, Changchun 130021, China
Many phytochemicals show promise in cancer prevention and treatment, but their low aqueous solubility, poor stability, unfavorable bioavailability, and low target specificity make administering them at therapeutic doses unrealistic. This is particularly true for (-)-epigallocatechin gallate, curcumin, quercetin, resveratrol, and genistein. There is an increasing interest in developing novel delivery strategies for these natural products. Liposomes, micelles, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers and poly (lactide-co-glycolide) nanoparticles are biocompatible and biodegradable nanoparticles. Those nanoparticles can increase the stability and solubility of phytochemicals, exhibit a sustained release property, enhance their absorption and bioavailability, protect them from premature enzymatic degradation or metabolism, prolong their circulation time, improve their target specificity to cancer cells or tumors via passive or targeted delivery, lower toxicity or side-effects to normal cells or tissues through preventing them from prematurely interacting with the biological environment, and enhance anti-cancer activities. Nanotechnology opens a door for developing phytochemical-loaded nanoparticles for prevention and treatment of cancer.
Key words:    Nanoparticles    Cancer    Biocompatible    Biodegradable    (-)-Epigallocatechin Gallate    Curcumin    Quercetin    Resveratrol    Genistein   
Received: 2015-05-26   Revised:
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