CN: 32-1845/R
ISSN: 2095-6975
Cite this paper:
Rachel A. Ness, Duane D. Miller, Wei LI. The role of vitamin D in cancer prevention[J]. Chinese Journal of Natural Medicines, 2015, 13(7): 481-497

The role of vitamin D in cancer prevention

Rachel A. Ness, Duane D. Miller, Wei LI
Department of Pharmaceutical Sciences, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA
Vitamin D, also known as cholecalciferol, is the precursor to the active steroid hormone 1, 25-dihydroxyvitamin D3 (calcitriol; 1, 25(OH)2D3). The main physiological role for 1, 25(OH)2D3 is to regulate calcium and inorganic phosphate homeostasis for bone health. More recently, vitamin D has been investigated for its effects in the prevention and treatment of a variety of diseases such as cancer, autoimmune disorders, and cardiovascular disease. Preclinical data strongly support a role for vitamin D in the prevention of cancer through its anti-proliferative, pro-apoptotic, and anti-angiogenic effects on cells. Epidemiologic and clinical studies have shown mixed data on the correlation between serum vitamin D levels and cancer risk. This report seeks to outline results from the most recent preclinical and clinical studies investigating the potential role of vitamin D in cancer prevention.
Key words:    Vitamin D    Calcitriol    Cancer prevention    Cancer prognosis    Vitamin D deficiency   
Received: 2015-05-10   Revised:
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Articles by Rachel A. Ness
Articles by Duane D. Miller
Articles by Wei LI