CN: 32-1845/R
ISSN: 2095-6975
Cite this paper:
0
YAN Shi-Kai, LIU Run-Hui, JIN Hui-Zi, LIU Xin-Ru, YE Ji, SHAN Lei, ZHANG Wei-Dong. “Omics” in pharmaceutical research:overview, applications, challenges, and future perspectives[J]. Chinese Journal of Natural Medicines, 2015, 13(1): 3-21

“Omics” in pharmaceutical research:overview, applications, challenges, and future perspectives

YAN Shi-Kai1, LIU Run-Hui2, JIN Hui-Zi1, LIU Xin-Ru2, YE Ji2, SHAN Lei2, ZHANG Wei-Dong1,2,3
1 School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China;
2 School of Pharmacy, Second Military Medical University, Shanghai 200433, China;
3 Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China
Abstract:
In the post-genomic era, biological studies are characterized by the rapid development and wide application of a series of "omics" technologies, including genomics, proteomics, metabolomics, transcriptomics, lipidomics, cytomics, metallomics, ionomics, interactomics, and phenomics. These "omics" are often based on global analyses of biological samples using high through-put analytical approaches and bioinformatics and may provide new insights into biological phenomena. In this paper, the development and advances in these omics made in the past decades are reviewed, especially genomics, transcriptomics, proteomics and metabolomics; the applications of omics technologies in pharmaceutical research are then summarized in the fields of drug target discovery, toxicity evaluation, personalized medicine, and traditional Chinese medicine; and finally, the limitations of omics are discussed, along with the future challenges associated with the multi-omics data processing, dynamics omics analysis, and analytical approaches, as well as amenable solutions and future prospects.
Key words:    Omics    Genomics    Transcriptomics    Proteomics    Metabolomics    Target Discovery    Toxicity Assessment    Personalized Medicine    Traditional Chinese Medicine   
Received: 2014-10-13   Revised:
Tools
PDF (755 KB) Free
Print this page
Email this article to others
Authors
Articles by YAN Shi-Kai
Articles by LIU Run-Hui
Articles by JIN Hui-Zi
Articles by LIU Xin-Ru
Articles by YE Ji
Articles by SHAN Lei
Articles by ZHANG Wei-Dong
References:

Related Articles:
1.KONG Ming, XU Jun, LIU Huan-Huan, XU Jin-Di, LI Xiu-Yang, LU Min, WANG Chun-Ru, CHEN Hu-Biao, LI Song-Lin.Effects of boiling duration in processing of White Paeony Root on its overall quality evaluated by ultra-high performance liquid chromatography quadrupole/time-of-flight mass spectrometry based metabolomics analysis and high performance liquid chromatography quantification[J]. Chinese Journal of Natural Medicines, 2017,15(1): 62-70
2.WANG Zhuo, LIU Jian-Qun, XU Jin-Di, ZHU He, KONG Ming, ZHANG Guo-Hua, DUAN Su-Min, LI Xiu-Yang, LI Guang-Fu, LIU Li-Fang, LI Song-Lin.UPLC/ESI-QTOF-MS-based metabolomics survey on the toxicity of triptolide and detoxication of licorice[J]. Chinese Journal of Natural Medicines, 2017,15(6): 474-480
3.GUO Qing, ZHANG Qian-Qian, CHEN Jia-Qing, ZHANG Wei, QIU Hong-Cong, ZHANG Zun-Jian, LIU Bu-Ming, XU Feng-Guo.Liver metabolomics study reveals protective function of Phyllanthus urinaria against CCl4-induced liver injury[J]. Chinese Journal of Natural Medicines, 2017,15(7): 525-533
4.JIA Yan, ZHANG Zheng-Zheng, WEI Yu-Hai, Qin Xue-Mei, LI Zhen-Yu.Metabolomics coupled with similarity analysis advances the eluci-dation of the cold/hot properties of traditional Chinese medicines[J]. Chinese Journal of Natural Medicines, 2017,15(8): 631-640
5.ZHANG Mo-Han, CHEN Jia-Qing, GUO Hui-Min, LI Rui-Ting, GAO Yi-Qiao, TIAN Yuan, ZHANG Zun-Jian, HUANG Yin.Combination of LC/MS and GC/MS based metabolomics to study the hepatotoxic effect of realgar nanoparticles in rats[J]. Chinese Journal of Natural Medicines, 2017,15(9): 684-694
6.LIU Si-Yi, CAI Wei, WANG Fei, LIU Ying, SHANG Zhan-Peng, ZHANG Xiu-Ping, WANG Zi-Jian, LU Jian-Qiu, ZHANG Jia-Yu.UHPLC-LTQ-Orbitrap-based metabolomics coupled with metabolomics pathway analysis method for exploring the protection mechanism of Kudiezi injection in a rat anti-ischemic cerebral reperfusion damage model [J]. Chinese Journal of Natural Medicines, 2017,15(12): 955-960
7.LV Meng-Ying, SUN Jian-Bo, WANG Min, FAN Hong-Yan, ZHANG Zun-Jian, XU Feng-Guo.Comparative analysis of volatile oils in the stems and roots of Ephedra sinica via GC-MS-based plant metabolomics[J]. Chinese Journal of Natural Medicines, 2016,14(2): 133-140
8.ZHOU Xiao-Hang, ZHANG Ai-Hua, WANG Liang, TAN Yun-Long, GUAN Yu, HAN Ying, SUN Hui, WANG Xi-Jun.Novel chinmedomics strategy for discovering effective constituents from ShenQiWan acting on ShenYangXu syndrome[J]. Chinese Journal of Natural Medicines, 2016,14(8): 561-581
9.ZHANG Dong-Mei, FENG Li-Xing, LI Lu, LIU Miao, JIANG Bao-Hong, YANG Min, LI Guo-Qiang, WU Wan-Ying, GUO De-An, LIU Xuan.Nano-LC-ESI MS/MS analysis of proteins in dried sea dragon Solenognathus hardwickii and bioinformatic analysis of its protein expression profiling[J]. Chinese Journal of Natural Medicines, 2016,14(9): 709-713
10.DONG Hui, YAN Guang-Li, HAN Ying, SUN Hui, ZHANG Ai-Hua, LI Xian-Na, WANG Xi-Jun.UPLC-Q-TOF/MS-based metabolomic studies on the toxicity mechanisms of traditional Chinese medicine Chuanwu and the detoxification mechanisms of Gancao, Baishao, and Ganjiang[J]. Chinese Journal of Natural Medicines, 2015,13(9): 687-698
11.WANG Xi-Jun, YAN Guang-Li, ZHANG Ai-Hua, SUN Hui, PIAO Cheng-Yu, LI Wei-Yun, SUN Chang, WU Xiu-Hong, LI Xing-Hua, CHEN Yun.Metabolomics and proteomics approaches to characterize and assess proteins of bear bile powder for hepatitis C virus[J]. Chinese Journal of Natural Medicines, 2013,11(6): 653-665
12.SUN Hui, HAN Ying, ZHANG Ai-Hua, MENG Xiang-Cai, WANG Zhen-Yue, SUN Wen-Jun, SUN Hai-Feng, WANG Xi-Jun.UPLC-MS based metabolic profiling of the phenotypes of Acanthopanax senticosus reveals the changes in active metabolites distinguishing the diversities of the plant grown in northeast area of China[J]. Chinese Journal of Natural Medicines, 2012,10(3): 196-206