CN: 32-1845/R
ISSN: 2095-6975
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Ravichandran Senthilkumar, CHEN Bao-An, CAI Xiao-Hui, FU Rong. Anticancer and multidrug-resistance reversing potential of traditional medicinal plants and their bioactive compounds in leukemia cell lines[J]. Chinese Journal of Natural Medicines, 2014, 12(12): 881-894

Anticancer and multidrug-resistance reversing potential of traditional medicinal plants and their bioactive compounds in leukemia cell lines

Ravichandran Senthilkumar1,2, CHEN Bao-An1,2, CAI Xiao-Hui1,2, FU Rong3
1 Department of Neoplastic Hematologic Disorders(Medical Science Key Subject of Jiangsu Province), Zhongda Hospital, Schoool of Medicine, Southeast University, Nanjing 210009, China;
2 Department of Oncology, School of Medicine, Southeast University, Nanjing 210009, China;
3 State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China
Abstract:
Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases.It occurs in cultured tumor cell lines,as well as in human cancers.Therefore,it is critical to develop novel anticancer drugs with multidrug-resistance modulating potential to increase the survival rate of leukemia patients.Plant-derived natural products have been used for the treatment of various diseases for thousands of years.This review summarizes the anticancer and multidrug-resistance reversing properties of the extracts and bioactive compounds from traditional medicinal plants in different leukemia cell lines.Further mechanistic studies will pave the road to establish the anticancer potential of plant-derived natural compounds.
Key words:    Traditional medicinal plants    Leukemia    Multidrug resistance(MDR)    Reversal multidrug resistance    Apoptosis   
Received: 2013-12-18   Revised:
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Articles by Ravichandran Senthilkumar
Articles by CHEN Bao-An
Articles by CAI Xiao-Hui
Articles by FU Rong
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