CN: 32-1845/R
ISSN: 2095-6975
Cite this paper:
WEI Shu-Yong, CHEN Yi, XU Xiao-Yu. Progress on the pharmacological research of puerarin:a review[J]. Chinese Journal of Natural Medicines, 2014, 12(6): 407-414

Progress on the pharmacological research of puerarin:a review

WEI Shu-Yong1,2, CHEN Yi1, XU Xiao-Yu1
1 Pharmaceutical College of Southwest University & College of Chinese Medicine;Chongqing Engineering Research Center for Pharmacodynamics Evaluation, Chongqing 400716, China;
2 Rongchang Campus of Southwest University, Rongchang 402460, China
Contemporary pharmacological research has demonstrated that puerarin,the most important phytoestrogen extracted from Pueraria lobata(Willd.) Ohwi,has protecting functions on the cardiovascular system,nervous system,osteoporosis,liver injury,and inflammation in vivo and in vitro.Most of these research studies focused on inhibiting oxidative stress and apoptosis through regulating various bioactivators and signal pathways.Among these,superoxide dismutase(SOD),endothelial nitric oxide synthase(eNOS) and malondialdehyde(MDA),and PI3K/Akt,MAPK,and NF-κB are of great importance.The data cited in this review were mainly obtained from articles listed in PubMed and Elsevier SDOL published from 1959 to 2013,and the search term used was "puerarin".
Key words:    Puerarin    Cardiovascular protection    Neuroprotection    Osteoporosis    Liver injury    Inflammation   
Received: 2013-04-20   Revised:
PDF (480 KB) Free
Print this page
Email this article to others
Articles by WEI Shu-Yong
Articles by CHEN Yi
Articles by XU Xiao-Yu

Related Articles:
1.YUAN Si-Yuan, SHENG Tong, LIU Lian-Qi, ZHANG Yun-Ling, LIU Xue-Mei, MA Tao, ZHENG Hong, YAN Yan, ISHIMI Yoshiko, WANG Xin-Xiang.Puerarin prevents bone loss in ovariectomized mice and inhibits osteoclast formation in vitro[J]. Chinese Journal of Natural Medicines, 2016,14(4): 265-269
2.CHEN Mi, WANG Tao, JIANG Zhen-Zhou, SHAN Chun, WANG Hao, WU Mei-Juan, ZHANG Shuang, ZHANG Yun, ZHANG Lu-Yong.Anti-inflammatory and hepatoprotective effects of total flavonoid C-glycosides from Abrus mollis extracts[J]. Chinese Journal of Natural Medicines, 2014,12(8): 590-598
3.XIE Yuan, HAO Hai-Ping, WANG Hong, WANG Zhao-Xian, WANG Guang-Ji.Reversing effects of silybin on TAA-induced hepatic CYP3A dysfunction through PXR regulation[J]. Chinese Journal of Natural Medicines, 2013,11(6): 645-652