CN: 32-1845/R
ISSN: 2095-6975
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Pandian Vijayabaskar, Noormohamed Vaseela, Ganapathy Thirumaran. Potential antibacterial and antioxidant properties of a sulfated polysaccharide from the brown marine algae Sargassum swartzii[J]. Chinese Journal of Natural Medicines, 2012, 10(6): 421-428

Potential antibacterial and antioxidant properties of a sulfated polysaccharide from the brown marine algae Sargassum swartzii

Pandian Vijayabaskar1, Noormohamed Vaseela1, Ganapathy Thirumaran2
1 P. G. Research Department of Microbiology, Ayya Nadar Janaki Ammal College(Autonomous), Sivakasi-626 124, Tamil Nadu, India;
2 Institute of Hydrobiology, Key Institute of Aquatic Eutrophication and Control of Harmful Algal Blooms of Guangdong Higher Education Institutes, Engineering Research Centre of Tropical and Subtropical Aquatic Ecological Engineering, Ministry of Education, Jinan University, Guangzhou 510632, China
Abstract:
AIMS: Sulfated polysaccharide extracted from the brown algae Sargassum swartzii was studied for antioxidant potential. METHODS: The extracted sulfated polysaccharide was analyzed for physico-chemical characteristics, TAC, reducing power, free radical scavenging potentials (DPPH, ABTS, H2O2 radical) and antibacterial properties. RESULTS: The extract showed a high percentage of carbohydrate (7.40 ± 0.63)%, followed by sulfate (5.3 ± 1.54)%. The highest antioxidant activity was observed in ABTS (55 ± 3.61)%, followed by H2O2 (47.23 ± 2.81)% and DPPH (25.33 ± 2.52)%; significant differences were observed at (P ≥ 0.05). Among the ten human pathogenic strains tested, E. coli was the more sensitive. The characterization and mobility of the sulfated polysaccharide was examined by the FT-IR spectrum and assayed by agarose gel electrophoresis which showed highest mobility at higher pH buffer in carbonate-bicarbonate (pH 10) buffer. The molecular weight of the sulfated polysaccharide was determined by gradient PAGE and was found to be 50 KDa. Finally, GC-MS analysis revealed the presence of peaks corresponding to dimethyl-4-nitroaniline (26.34%). CONCLUSIONS: It is suggested that the sulfated polysaccharide from Sargassum swartzii could be a better source of natural antioxidant, as well as an antibacterial agent.
Key words:    Sargassum swartzii    Sulfated polysaccharide    Antibacterial    Antioxidant    Characterization   
Received: 2011-10-17   Revised:
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