CN: 32-1845/R
ISSN: 2095-6975
ZHAO Ya-Zheng, ZHANG Yuan-Yuan, HAN Han, FAN Rui-Ping, HU Yang, ZHONG Liang, KOU Jun-Ping, YU Bo-Yang. Advances in the antitumor activities and mechanisms of action of steroidal saponins[J]. 中国天然药物英文, 2018, 16(10): 732-748

Advances in the antitumor activities and mechanisms of action of steroidal saponins

ZHAO Ya-Zheng, ZHANG Yuan-Yuan, HAN Han, FAN Rui-Ping, HU Yang, ZHONG Liang, KOU Jun-Ping, YU Bo-Yang
Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Complex Prescription of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China
The steroidal saponins are one of the saponin types that exist in an unbound state and have various pharmacological activities, such as anticancer, anti-inflammatory, antiviral, antibacterial and nerves-calming properties. Cancer is a growing health problem worldwide. Significant progress has been made to understand the antitumor effects of steroidal saponins in recent years. According to reported findings, steroidal saponins exert various antitumor activities, such as inhibiting proliferation, inducing apoptosis and autophagy, and regulating the tumor microenvironment, through multiple related signaling pathways. This article focuses on the advances in domestic and foreign studies on the antitumor activity and mechanism of actions of steroidal saponins in the last five years to provide a scientific basis and research ideas for further development and clinical application of steroidal saponins.
关键词:    Steroidal saponins    Tumor    Mechanism   
收稿日期: 2018-01-20
KOU Jun-Ping,;YU Bo-Yang,
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ZHAO Ya-Zheng 在本刊中的所有文章
ZHANG Yuan-Yuan 在本刊中的所有文章
HAN Han 在本刊中的所有文章
FAN Rui-Ping 在本刊中的所有文章
HU Yang 在本刊中的所有文章
ZHONG Liang 在本刊中的所有文章
KOU Jun-Ping 在本刊中的所有文章
YU Bo-Yang 在本刊中的所有文章
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