CN: 32-1845/R
ISSN: 2095-6975
Mahmood Brobbey Oppong, LI Yang, Prince Osei Banahene, FANG Shi-Ming, QIU Feng. Ethnopharmacology, phytochemistry, and pharmacology of Sterculia lychnophora Hance (Pangdahai)[J]. 中国天然药物英文, 2018, 16(10): 721-731

Ethnopharmacology, phytochemistry, and pharmacology of Sterculia lychnophora Hance (Pangdahai)

Mahmood Brobbey Oppong1,2, LI Yang1, Prince Osei Banahene1, FANG Shi-Ming1, QIU Feng1
1 Tianjin State Key Laboratory of Modern Chinese Medicine and School of Chinese Materia Medica, Tianjin University of Tradi-tional Chinese Medicine, Tianjin 300193, China;
2 Department of Pharmaceutical Chemistry, School of Pharmacy, College of Health Sciences, University of Ghana, P. O. Box, LG 43, Legon, Ghana
The matured, ripen, and dried seeds of Scaphium affine (Mast.) Pierre, known as Pangdahai (PDH) in Chinese and recorded as Sterculia lychnophora Hance (scientific synonym) in the 2015 edition of the Chinese Pharmacopeia, have been widely used in traditional Chinese medicine, Japanese folk medicine, Vietnamese traditional medicine, traditional Thai medicine and Indian traditional medicine. The decoctions of the seeds are used as a remedy for pharyngitis, laryngitis, constipation, cough, menorrhagia, and pain management. This review is aimed at fully collating and presenting a systematic and comprehensive overview of the ethnopharmacological uses of PDH, its phytochemical constituents, pharmacological activities, and toxicological profile. Additionally, this review aims to reveal the therapeutic potentials as well as the important scientific gaps in the research of this traditional medicine that need to be filled so as to provide a comprehensive data for its development, utilization and application. From our extensive review of literatures, the teas (water decoctions) of PDH, which largely contain very polar constituents like polysaccharides, are used in the treatment of constipation, pharyngitis, and pain traditionally and ethno-medicinally and their use have been justified by pharmacological studies carried out on the polysaccharides and aqueous extracts. Additionally, this review has revealed that the organic (ethanolic and methanolic) extracts of PDH possess diverse pharmacological (anti-inflammatory, anti-ulcer, anti-pyretic, anti-microbial, anti-obesity and analgesic) effects, yet have received little attention. Most studies on PDH have been focused on the polysaccharides (large molecular weight metabolites), resulting in a major scientific gap in our knowledge on PDH. Furthermore, this review has also shown that few studies have been done in the areas of quality control, pharmacokinetics, and toxicological studies of PDH.
关键词:    Sterculia lychnophora Hance    Pangdahai    Metabolites    Pharmacology   
收稿日期: 2018-04-30
FANG Shi-Ming,Tel:86-22-59596223,;QIU Feng,
PDF(1372 KB) Free
Mahmood Brobbey Oppong 在本刊中的所有文章
LI Yang 在本刊中的所有文章
Prince Osei Banahene 在本刊中的所有文章
FANG Shi-Ming 在本刊中的所有文章
QIU Feng 在本刊中的所有文章
[1] Li C. Sterculia lychnophora Hance (Pangdahai, Malva Nut Tree), In:Liu Y, Wang Z, Zhang J. (eds) Dietary Chinese Herbs[M]. Vienna:Springer, 2015:535-542.
[2] Jin SY. Modern understanding and prospect on Chinese medicine:affinal drug and diet[J]. J Zhejiang Chin Med Univ, 2011, 35(1):19-20.
[3] Wang ZS. Medicine food homology and differences.[J]. J Chengdu Univ Tradit Chin Med, 2008, 31(3):58-59.
[4] Chau CF, Wu SH. The development of regulations for 290 Chinese herbal medicines for both medicinal and food uses[J]. Trends Food Sci Technol, 2006, 17(6):313-323.
[5] Chinese Pharmacopoeia Commission. Pharmacopoeia of the People's Republic of China[M]. Beijing:Chinese Medical Science and Technology Press, 2015.
[6] Sharma B, Gupta S, Sharma K. Natural folk remedy for menorrhagia[J]. J Info Knowl Res Hum Soc Sci, 2012, 2(1):86-88.
[7] Guo JX, But PPH, Kmura T, et al. International Collation of Traditional and Folk Medicine, Vol 4[M]. Singapore:World Scientific Publishing Co. pte. Ltd., 2001:59-60.
[8] Phlicharoenphon W, Gritsanapan W, Peungvicha P, et al. Determination of antioxidant activity, inhibitory effect on glucose absorption and acute toxicity of Scaphium scaphigerum fruit gel powder[J]. J Health Res, 2017, 31(4):289-296.
[9] Latainin Y. Effect of Scaphium scaphigerum (G.Don) Guib & Planoh on abdominal adipose tissue and weight loss in Thai obesity[D]. Dissertation submitted in partial fulfilment of the requirement for the degree of Master of Science in Medical Physiology, Khon Kaen University, 2010.
[10] Danish International Development Agency. Cambodian Tree Species[M]. FA:CTSP, 2004.
[11] Baird IG, Bounphasy S. Non-timber forest product use, management and tenure in Pathoumphone district, Champasak province, Southern Laos[M]. Lao PDR:Remote village education support project, Global Association for People and the Environment (GAPE), 2002.
[12] Ogale SC, Kasture SB, Kasture VS, et al. Screening of methanolic extract of Sterculia scaphigera seeds for ulcer protective and antioxidant activity[J]. World J Pharm Pharm Sci, 2015, 4(1):1332-1346.
[13] Dhage P, Kasture SB, Mohan M. Analgesic, anti-inflammatory, antioxidant and antiulcer activity of ethanolic extract of Sterculia Scaphigera Hance (Sterculi-aceae) seeds in mice and rats[J]. Int J Biol Pharm Res, 2015, 4(1):35-45.
[14] Ai L, Wu J, Na C, et al. Extraction, partial characterization and bioactivity of polysaccharide from boat-fruited Sterculia seeds[J]. Int J Biol Macromol, 2012, 51:815-818.
[15] Gao LF, Cao LG, Tian M, et al. Weight-losing effect of a novel fatty acid synthase inhibitor from extract of Pangdahai on rats with diet-induced obesity[J]. J Capital Med Univ, 2011, 32(4):541-544.
[16] Zhao WH, Zhao CY, Gao LF, et al. The Novel Inhibitory effects of Pangdahai on fatty acid synthase[J]. IUBMB Life, 2008, 60(3):185-194.
[17] Li N, Gao A, Gang J, et al. Overview of pharmacological research of Sterculia lychnophora Hance[J]. J Anhui Agri Sci, 2011, 39(16):9609-9610.
[18] Surapanthanakorn P. Evaluation of analgesic, antipyretic and anti-inflammatory activities of ethanol extracts from Scaphium lychnophorum fruit in experimental animals[D]. A thesis submitted in partial fulfilment of the requirements for the degree of Master of Science in Pharmacology. Prince of Songkla University. 2010.
[19] Medicinal Plant Name Service[EB/OL]., (last accessed 15/12/2017).
[20] Flora of China[M]. 2007, 12:303-310.
[21] Wu Y, Cui SW, Wu J, et al. Structural characteristics and rheological properties of acidic polysaccharide from boat-fruited sterculia seeds[J]. Carbohydr Polym, 2012, 88(3):926-930.
[22] Wang RF, Yang X, Ma C, et al. Alkaloids from the seeds of Sterculia lychnophora (Pangdahai)[J]. Phytochemistry, 2003, 63(4):475-478.
[23] Jiang M, Zhang C, Cao H, et al. The role of Chinese medicine in the treatment of chronic diseases in China[J]. Planta Med, 2011, 77(9):873-881.
[24] Zhu CH. Clinical handbook of Chinese prepared medi-cines[M]. Brookline, Massachusetts:Paradigm publications, 1989:165.
[25] Bensky D, Scheid V, Ellis A, Barolet R. Chinese herbal medicine:formulas and strategies[M]. 2nd edition. USA:Eastland Press, 2015.
[26] Zheng DH. Honey and Sterculia lychnophora Hance (Pangdahai)-cure for chronic pharyngitis[J]. Apicult Chin, 2006, 57(2):58.
[27] Wei S. Oral cavity disinfectant[P]. Faming Zhuanli Shen-qing, CN 104922318 A 20150923, 2015.
[28] Luo Y. Herbal tea for treating oral topical le-sions-associated bad breath[P]. Faming Zhuanli Shenqing, CN 105613880 A 20160601, 2016.
[29] Zhang ZF. 112 cases of chronic pharyngitis treated with Sterculia lychnophora Hance (Pangdahai)[J]. J Tradit Chin Med, 2003, 21(10):1649-1650.
[30] Wang XQ, Wang J. Treatment of 160 cases of chronic pharyngitis with Jin Xiong Yan Bi Ke and Pangdahai[J]. Clin Pract, 13(1):62.
[31] Yu Z. Clinical effect of Qin Qin oral liquid in the treatment of oral ulcer[J]. Chin Form Med Res, 2016, 14(8):147-149.
[32] Xu Q, Wu F, Xu X. Clinical evaluation of Qin Qin oral liquid in the treatment of chronic cough in young people[J]. Hebei J Tradit Chin Med, 2015, 38(10):1511-1514.
[33] Handa SS, Rakesh DD, Vasisht K. Compendium of Me-dicinal and Aromatic Plants, Vol. 2[M]. Asia:UNIDO Publications, 2006:74.
[34] Phongphachanh S. A Survey report:Supply capacity sur-vey on medicinal herbs in Lao PDR[M]. 2005.
[35] Toki S, Kondo M, Maeda T. Cosmetic compositions, bath preparations, and cleansing compositions containing plant extracts as moisturizers[P]. Kokai TokkyoKoho, JP 2000143437 A 20000523, 2000.
[36] Hansen KK, Top N. Natural Forest Benefits and Economic Analysis of Natural Forest Conversion in Cambodia[M]. Cambodia Development Resource Institute, 2006:33.
[37] Foppes J, Ketpanh S. The use of Non-Timber Forest Products in Lao PDR[M]. Paper presented at the workshop on Sustainable Management of Non-Wood Forest Products, IDEAL, UPM, Serdang, Selangor, Ma-laysia, 1997.
[38] Li H. Feed containing traditional Chinese medicine for mountain black-bone chickens[P]. Faming Zhuanli Shenqing, CN 102018107 A 20110420, 2011.
[39] Chinese Academy of Medical Sciences. Chinese Tradi-tional Medicine Records, Volume 3[M]. Beijing:People's Medical Publishing House, 1984:538-541.
[40] Wu Y. Study on structure and functional properties of an acidic polysaccharide isolated from boat-fruited Sterculia seeds[D]. Doctoral dissertation of Jiangnan University, 2007.
[41] Klinsukon M, Somboonpanyakul P, Laohakunjit N. Ex-traction and chemical composition of gum from Malva nut seeds[J]. J Agric Sci, 2009, 40(3):333-336.
[42] Chen JM, Li WK, Liu HL. Chemical studies on Sterculia lychnophora[J]. J Chin Mater Med 1995, 18(11):567-570.
[43] Wu Y, Cui SW, Tang J, et al. Preparation, partial characterization and bioactivity of water-soluble polysaccharides from boat-fruited sterculia seeds[J]. Carbohydr Polym 2007, 70(4):437-443.
[44] Somboonpanyakul P, Wang Q, Cui WS, et al. Malva nut gum. (Part I):Extraction and physicochemical char-acterization[J]. Carbohydr Polym, 2006, 64(2):247-253.
[45] Wang RF, Wu XW, Di G. Two cerebrosides isolated from the seeds of Sterculia lychnophora and their neuroprotec-tive effect[J]. Molecules, 2013, 18(1):1181-1187.
[46] Wang RF, Yang XW, Ma CM, et al. Analysis of fatty acids in the seed of Sterculia lychnophora by GC-MS[J]. Chin J Chin Mater Med, 2003, 28(6):533-535.
[47] Du L, Sun S, Yu L, et al. Pharmacodynamics of Sterculia lychnophora semen from home and abroad on anti-infla-mmation and small intestine's peristalsis in mice[J]. Chin Med Mat, 1995, 18(8):409-411.
[48] Lams UDP, Hoang DN, Lee HB, et al. Depigmenting effect of Sterculia lychnophora on B16F10 melanoma and C57BL/6 melan-a cells[J]. Korean J Chem Eng, 2011, 28(4):1074-1077.
[49] Salam MA, Matsumoto N, Matin K, et al. Establishment of an animal model using recombinant NOD. B10. D2 mice to study initial adhesion of oral streptococci[J]. Clin Diagn Lab Immunol, 2004, 11(2):379-386.
[50] Jeong SI, Kim BS, Keum KS, et al. Kaurenoic acid from Aralia continentalis inhibits biofilm formation of Streptococcus mutans[J]. Evid-Based Complement Altern Med, 2013:160592.
[51] Yang Y, Park BI, Hwang EH, et al. Composition analysis and inhibitory effect of Sterculia lychnophora against biofilm formation by Streptococcus mutans[J]. Evid-Based Complement Altern Med, 2016:8163150.
[52] Hwang EH, Yang Y, Park BI, et al. Oral disease prevention, alleviation or treatment composition containing extracts of Sterculia lychophora as active ingredient[P]. Kongkae Taeho Kongbo KR 2016067311 A 20160614, 2016.
[53] Palve A, Shetty P, Pimpliskar M, et al. Study on antibacte-rial and antifungal activities of Sterculia lychnophora extracts[J]. Int J Curr Microbiol Appl Sci, 2015, 4(11):336-341.
[54] Yu C, Zhu L. The experimental study on curing acute bacillary dysentery by Sterculiae lychnophora semen[J]. Res Tradit Chin Med, 1997, 32(1):46-48.
[55] Shetty P, Palve A, Pimpliskar M, et al. In-Silico docking analysis of Sterculia lychnophora compounds against proteins causing Alzheimer's disease[J]. Int J Eng Sci Inno Tech, 2014, 3(4):158-164.
[56] Witkowski A, Ghosal A, Joshi AK, et al. Head-to-head coiled arrangement of the subunits of the animal fatty acid synthase[J]. Chem Biol, 2004, 11(12):1667-1676.
[57] Kuhajda FP. Fatty acid synthase and cancer:new applica-tion of an old pathway[J]. Cancer Res, 2006, 66(12):5977-5980.
[58] Visca P, Sebastiani V, Pizer ES, et al. Immunohistochemi-cal expression and prognostic significance of FAS and GLUT1 in bladder carcinoma[J]. Anticancer Res, 2003, 23(1A):335-339.
[59] Swinnen JV, Roskams T, Joniau S, et al. Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer[J]. Int J Cancer, 2002, 98(1):19-22.
[60] Wang X, Tian WX. Green tea epigallocatechin gallate:a natural inhibitor of fatty acid synthase[J]. Biochem Biophys Res Commun, 2001, 288(5):1200-1206.
[61] Piyathilake CJ, Frost AR, Manne U. The expression of fatty acid synthase (FASE) is an early event in the devel-opment and progression of squamous cell carcinoma of the lung[J]. Hum Pathol, 2000, 31(9):1068-1073.
[62] Vergote D, Cren OC, Chopin V, et al. (-)-Epigallocatechin (EGC) of green tea induces apoptosis of human breast cancer cells but not of their normal counterparts[J]. Breast Cancer Res Treat, 2002, 76(3):195-201.
[63] Wang X, Song KSH, Guo QX, et al. The galloyl moiety of green tea catechins is the critical structural feature to inhibit fatty-acid synthase[J]. Biochem Pharm, 2003, 66(10):2039-2047.
[64] Zhang YM, Rock CO. Evaluation of epigallocatechin gallate and related plant polyphenols as inhibitors of the FabG and FabI reductases of bacterial type Ⅱ fatty acid synthase[J]. Biol Chem, 2004, 279(30):994-1001.
[65] Du YT, Wang X, Wu XD, et al. Keemun black tea extract contains potent fatty acid synthase inhibitors and reduces food intake and body weight of rats via oral administration[J]. J Enzyme Inhib Med Chem, 2005, 20(4):349-356.
[66] Wang. Modern pharmacology of Chinese Materia Medica[M]. Tianjin:Tianjin Science and Technology Press, 1997.
[67] Zhang S, Liu G, He J, et al. An experimental and clinical study on Sterculia lychnophora Hance:in vitro and in vivo inhibition of calcium oxalate crystal[J]. Chin J Urol, 1996, 17(1):51-53.
[68] Wang R, Wang X, Shen Y, et al. Experimental research on the effect of Sterculia scaphigera extract in preventing the formation of the calcium oxalate crystal[J]. J Chaohu Coll, 2014, 16(3):63-68.
[69] Palve A, Shetty P, Pimpliskar M, et al. HPTLC method for quality determination of phytochemical compounds in ex-tracts of Sterculia lychnophora[J]. Int J Res Ayurveda Pharm, 2015, 6(3):358-365.
[70] Wang RF, An YN, Yuan M, et al. Quality coherence evaluation of the seeds of Sterculia lychnophora commercially available in China based on HPLC fingerprint[J]. Chin J Exp Tradit Med Form, 2013, 19(17):73-76.
[71] Su JH, Zhang C, Zhong SS, et al. Quantitative analysis of aflatoxin in Sterculiae lychnophorae semen by HPLC-FLD after immunoaffinity column with post-column photochemical derivatization[J]. Chin J Exp Tradit Med Form, 2014, 2(15):75-77.
[72] Zhu B, Ma SC, Lin RC. A research survey on mycotoxins contamination of natural medicines[J]. Chin Pharm Affairs, 2009, 23(11), 26-1132.
[73] Tassaneeyakul W, Razzazi-Fazeli E, Porasuphatana S, et al. Contamination of aflatoxins in herbal medicinal products in Thailand[J]. Mycopathologia, 2004, 158(2):239-244.
[74] Bhatnagar D, Ehrlich KC, Cleveland TE. Molecular genetic analysis and regulation of aflatoxin biosynthesis[J]. Appl Microbiol Biotechnol, 2003, 61(2):83-93.
[75] Busby WF, Wogan GN. Aflatoxins, In:Chemical car-cinogens, Second edition, Vol 2, ACS Monograph 182, Searle,C.E (ed)[M]. Washington, DC, 1984:945-1136.
[76] European Pharmacopoeia Commission. European Pharmacopoeia[M]. Council of Europe, European Directorate for the Quality of Medicines (EDQM), 2011.