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WEI Shu-Yong, CHEN Yi, XU Xiao-Yu. Progress on the pharmacological research of puerarin:a review[J]. 中国天然药物英文, 2014, 12(6): 407-414

Progress on the pharmacological research of puerarin:a review

WEI Shu-Yong1,2, CHEN Yi1, XU Xiao-Yu1
摘要:
Contemporary pharmacological research has demonstrated that puerarin,the most important phytoestrogen extracted from Pueraria lobata(Willd.) Ohwi,has protecting functions on the cardiovascular system,nervous system,osteoporosis,liver injury,and inflammation in vivo and in vitro.Most of these research studies focused on inhibiting oxidative stress and apoptosis through regulating various bioactivators and signal pathways.Among these,superoxide dismutase(SOD),endothelial nitric oxide synthase(eNOS) and malondialdehyde(MDA),and PI3K/Akt,MAPK,and NF-κB are of great importance.The data cited in this review were mainly obtained from articles listed in PubMed and Elsevier SDOL published from 1959 to 2013,and the search term used was "puerarin".
关键词:    Puerarin    Cardiovascular protection    Neuroprotection    Osteoporosis    Liver injury    Inflammation   
收稿日期: 2013-04-20
XU Xiao-Yu:Prof.,Tel:86-23-68251225,Fax:86-23-68250761,E-mail:xuxiaoyu@swu.edu.cn
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