CN: 32-1845/R
ISSN: 2095-6975
Shah Unnati, Shah Ripal, Acharya Sanjeev, Acharya Niyati. Novel anticancer agents from plant sources[J]. 中国天然药物英文, 2013, 11(1): 16-23

Novel anticancer agents from plant sources

Shah Unnati1, Shah Ripal2, Acharya Sanjeev3, Acharya Niyati3
1 Pioneer Pharmacy Degree College, Vadodara-390019, India;
2 Sun Pharma Advanced Research Centre, Vadodara-390020, India;
3 Institute of Pharmacy, Nirma University, Sarkhej-Gandhinagar Highway, Ahmedabad-382481, India
Plants remain an important source of new drugs,new drug leads and new chemical entities.Plant based drug discovery resulted mainly in the development of anticancer and anti-infectious agents,and continues to contribute to the new leads in clinical trials.Natural product drugs play a dominant role in pharmaceutical care.Several plant-derived compounds are currently successfully employed in cancer treatment.There are many classes of plant-derived cytotoxic natural products studied for further improvement and development of drugs.New anticancer drugs derived from research on plant antitumor agents will be continuously discovered.The basic aim of this review is to explore the potential of newly discovered anticancer compounds from medicinal plants,as a lead for anticancer drug development.It will be helpful to explore the medicinal value of plants and for new drug discovery from them for the researchers and scientists around the globe.
关键词:    Cancer    Anticancer agents    Medicinal plants   
收稿日期: 2011-12-31
PDF(679 KB) Free
Shah Unnati 在本刊中的所有文章
Shah Ripal 在本刊中的所有文章
Acharya Sanjeev 在本刊中的所有文章
Acharya Niyati 在本刊中的所有文章
[1] Mesquite de MC,Paula de JE,Pessoa C,et al Cytotoxic activity of Brazilian Cerrado plants used in traditional medicine against cancer cell lines[J].J Ethnopharmacol,2009,123(2):439-445.
[2] Fouche G,Cragg GM,Pillay P,et al.In vitro anticancer screening of South African plants[J].J Ethnopharmacol,2008,119(3):455-461.
[3] Cragg GM,Newman DJ.Plants as a source of anti-cancer agents[J].J Ethnopharmacol,2005,100(1-2):72-79.
[4] Ames BN,Gold LS,Willett WC.The causes and prevention of cancer[J].Proc Natl Acad Sci USA,1995,92(12):5258-5265.
[5] Pandey G,Madhuri S.Medicinal plants:better remedy for neoplasm[J].Indian Drugs,2006,43(11):869-874.
[6] Rosangkima G,Prasad SB.Antitumour activity of some plants from Meghalaya and Mizoram against murine ascites Dolton's lymphoma[J].Indian J Exp Biol,2004,42:981-988.
[7] Madhuri S,Pandey G.Some dietary agricultural plants with anticancer properties[J].Plant Arch,2008,8(1):13-16.
[8] Sivalokanathan S,Ilayaraja M,Balasubramanium MP.Efficacy of Terminalia arjuna(Roxb.) on N-nitrosodiethylamine induced hepatocellular carcinoma in rats[J].Indian J Exp Biol,2005,43:264-267.
[9] Luduene RF.Multiple form of tubulin:different gene products and covalent modification[J].Int Rev Cytology,1998,178(13):207.
[10] Neoh CK.Typhonium divaricatum(Rodent Tuber):a promising local plant in the fight against cancer[J].Med J Malaysia.1992,47(1):86-88.
[11] Mehndiratta S,Kumar S,Kumar Meena A,et al.A review on lants a useful source of anti-cancer drugs[J].J Pharm Res,2011,4(1):264-271.
[12] Wani Mc,Taylor Hl,Wall Me,et al.Plant antitumor agents.VI.The isolation and structure of taxol,a novel antileukemic and antitumor agent from Taxus brevifolia[J].J Am Chem Soc,1971,93(13):2325-2327.
[13] Canel C,Moraes RM,Dayan FE,et al.Molecules of interest:podophyllotoxin podophyllotoxin[J].Phytochemistry,2000,54(2):115-120.
[14] Cirla A,Mann J.Combrestatins:from natural product to drug discovery[J].Nat Prod Rep,2003,20:558-564.
[15] Itokawa H,Wang X.Homoharringtonine and related compounds.In:Cragg GM,Kingston DGI.Newman D(eds) Anticancer Agents from Natural Products[M].Boca Raton,Florida:Brunner-Routledge Psychology Press,Taylor and Francis Group.2005:47-70.
[16] Peters B.New cancer therapies for 2007-looking to the future[J].Oncology Issues,2007:34-39.
[17] Da Rocha AB,Lopes RM,Schwartsmann G.Natural products in anticancer therapy[J].Curr Opin Pharmacol,2001,1(4):364-369.
[18] Westwell AD.Novel Antitumour molecules[J].Drug Discov Today,2003,8(1):47-50.
[19] Newcomb EW.Flavopiridol:pleiotropic biological effects enhance its anticancer activity[J].Anti Cancer Drugs,2004,15(5):411-419.
[20] Kinghorn AD.The discovery of drugs from higher plants.In:Gullo VP,editor.The Discovery of Natural Products with Therapeutic Potential[M].Boston,MA:Butterworth-Heinemann;1994.81-108.
[21] Newman DJ,Cragg GM,Snader KM.Natural products as sources of new drugs over the period 1981-2002[J].J Nat Prod,2003,66(7):1022-1037.
[22] Cragg GM,Newman DJ.A tale of two targets:Topoisomerase I and tubulin The Wall and Wani contribution to cancer chemotherapy[J].J Nat Prod,2004,67:232-244.
[23] Saklani A,Kutty SK.Plant-derived compounds in clinical trials[J].Drug Disc Today,2008,13(3-4):161-171.
[24] Butler MS.Natural products to drugs:natural product derived compounds in clinical trials[J].Nat Prod Rep,2005,22(2):162-195.
[25] Giovanella BC,Stehlin JS,Wall ME.DNA topoisomerase I-targeted chemotherapy of human colon cancer in xenografts[J].Science,1989,246(Nov-24):1046-1048.
[26] Giovanella BC,Stehlin JS,Hinz HR,et al.Preclinical evaluation of the anticancer activity and toxicity of 9-nitro-20(S)-camptothecin(Rubitecan)[J].Int J Oncol,2002,20:81-88.
[27] Ulukan H,Swaan PW.Camptothecins:a review of their chemotherapeutic potential[J].Drugs,2002,62(14):2039-2057.
[28] Singer JW,Shaffer S,Baker B,et al.Paclitaxel poliglumex(XYOTAX;CT-2103):an intracellularly targeted taxane[J].Anticancer Drugs,2005,16:243-254.
[29] Spigel DR,Greco FA.What is the role of novel taxanes in non-small-cell lung cancer[J].Clin Lung Cancer,2008,9(3):S116-S121.
[30] Jones RJ,Hawkins RE,Eatock MM,et al.A phase II open-label study of DHA-paclitaxel(Taxoprexin) by 2-h intravenous infusion in previously untreated patients with locally advanced or metastatic gastric or oesophageal adenocarcinoma[J].Cancer Chemother Pharmacol,2008,61(3):435-441.
[31] Anonymous.Vincristine liposomal——INEX:lipid-encapsulated vincristine,onco TCS,transmembrane carrier system-vincristine,vincacine,vincristine sulfate liposomes for injection[J].Drugs in R & D.2004,5(2):119-123.
[32] Erickson HP.Negatively stained vinblastine aggregates[J].Ann N.Y Acad Sci,1975,253(Jun-30):51-52.
[33] Na GC,Timasheff SN.In vitro vinblastine-induced tubulin paracrystals[J].J Biol Chem,1982,257(11):10387-10391.
[34] Jordan MA,Margolis RL,Himes RH.Identification of a distinct class of vinblastine binding sites on microtubules[J].J Mol Biol,1986,187(1):61-73.
[35] Kanat O,Ender K,Fatih O,et al.Single-agent vinorelbine as third-line chemotherapy for refractory non-small cell lung cancer[J].Turk J Cancer,2006,36(3):133-138.
[36] European medicines agency evaluation of medicines for human use[R].CHMP Assessment Report for Javlor,370293/2009.
[37] Letourneau R,Ghassan K,Abou-A,et al.Randomized Phase III study of exatecan and gemcitabine compared with gemcitabine alone in untreated advanced pancreatic pancer[J].J Clin Oncol,2006,24(27):4441-4447.
[38] Georgaki S,Skopeliti M,Tsiatas M,et al.Phenoxodiol,an anticancer isoflavene,induces immunomodulatory effects in vitro and in vivo[J].J Cell Mol Med,2009,13,(9):3929-3938.
[39] Bradbury,J.From Chinese medicine to anticancer drug[J].Drug Discov Today,2005,10(17):1131-1132.
[40] Quesada AR,Muñoz-Chápuli R,Medina MA.Anti-angiogenic drugs:from bench to clinical trials[J].Med Res,2006,26:483-530.
[41] Westwell AD.Novel antitumour molecules[J].Drug Discov Today,2003,8(20):47-50.
[42] Hamann MT,Otto CS,Scheuer PJ.Kahalalides:bioactive peptides from a marine mollusk Elysia rufescens and its algal diet Bryopsis sp[J].J Org Chem,1996,61(19):6594-6600.

1.Bibin G. Anand, C. K. Navin Thomas, S. Prakash.In vitro cytotoxicity and antimicrobial activity of Talaromyces flavus SP5 inhabited in the marine sediment of Southern Coast of India[J]. 中国天然药物, 2016,14(12): 913-921